TASTE PATHWAYS TO HYPOTHALAMUS AND AMYGDALA
TASTE PATHWAYS TO HYPOTHALAMUS AND AMYGDALA
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DOI：
10.1002/cne.901660103
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发表时间：
1976-01-01
影响因子：
2.5
通讯作者：
NORGREN, R
中科院分区：
文献类型：
--
作者：
NORGREN, R
用氚化脯氨酸放射自显影和丘脑和杏仁核电极对脑桥神经元的逆向激活，追踪大鼠背侧脑桥的3阶味觉中继投射。标记的轴突聚集在中央被盖束中，并上升到腹基底复合体内侧延伸的丘脑味觉区。大部分纤维仍在同侧，但少数交叉在脑桥吻侧和中脑。最大的交叉发生在丘脑末端的水平。许多纤维束继续吻侧通过丘脑味觉区下方，穿过内侧丘系并沿着内囊（IC）的背内侧角伸展。在这一水平的终端领域的上限IC从丘脑底核到远外侧下丘脑。标记的轴突逐渐穿透内囊，并在整个潜在的无名质分支。这一终末区向外侧延伸至杏仁核中央核的吻端，在其尾端有密集的标记。在杏仁核的尾端，终纹的1个组成部分中可见标记纤维。这些纤维随后在背侧丘脑进入一个较小的，但同样致密的终末区在背外侧床核的终纹。电生理数据表明，位于杏仁核中央核内或附近的电极可以逆向激活脑桥味觉单位。由于许多相同的单位也可以从丘脑味觉区驱动，放射自显影追踪的轴突中至少有一些可能将味觉信息传递到下丘脑和杏仁核。
The projections of a 3rd order gustatory relay in the dorsal pons of rats were traced using tritiated proline autoradiography and antidromic activation of pontine neurons from electrodes in the thalamus and amygdala. Labeled axons collected in the central tegmental tract and ascended to the thalamic taste area in the medial extension of the ventrobasal complex. The majority of the fibers remained ipsilateral, but a few crossed in the rostral pons and midbrain. The largest crossing occurred at the level of the thalamic termination. Many fascicles of fibers continued rostrally by passing beneath the thalamic taste area, piercing the medial lemniscus and spreading out along the dorsomedial corner of the internal capsule (IC). The terminal field at this level capped IC from the subthalamic nucleus down into the far-lateral hypothalamus. Labeled axons gradually penetrated through the internal capsule and ramified throughout the underlying substantia innominata. This terminal zone extended laterally into the rostral end of the central nucleus of the amygdala, which was densely labeled to its caudal extremity. At the caudal end of the amygdala labeled fibers were visible in 1 component of the stria terminalis. These fibers were followed over the dorsal thalamus into a smaller, but equally dense terminal area in the dorsolateral bed nucleus of the stria terminalis. The electrophysiological data demonstrated that pontine gustatory units can be antidromically activated by electrodes located in or near the central nucleus of the amygdala. Since many of the same units can also be driven from the thalamic taste area, at least some of the axons traced autoradiographically probably convey gustatory information to the hypothalamus and amygdala.