Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (The Framingham Heart Study)
Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (The Framingham Heart Study)
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DOI：
10.1016/s0002-9149(98)01064-9
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发表时间：
1999-03-15
影响因子：
2.8
通讯作者：
Benjamin, EJ
中科院分区：
文献类型：
--
作者：
Singh, JP;Evans, JC;Benjamin, EJ
关于一般人群中瓣膜返流的患病率和决定因素的信息很少。本研究旨在评估二尖瓣（MR）、三尖瓣（TR）和主动脉瓣（AR）返流的患病率和临床决定因素。在弗雷明汉研究中，对参加常规检查的1，696名男性和1，893名女性（年龄54 ± 10岁）进行了彩色多普勒超声心动图检查。排除技术较差的超声心动图后，MR、TR和AR从微量到重度进行定性分级。多元逻辑回归分析用于检查临床变量与MR和TR（大于或等于轻度严重程度）和AR（大于或等于痕量严重程度）的相关性。19.0%和14.8%的男性和19.1%和18.4%的女性中分别观察到≥轻度严重程度的MR和TR，13.0%的男性和8.5%的女性中≥痕量严重程度的AR。MR的临床决定因素为年龄（比值比[OR] 1.3/9.9岁，95%置信区间[CI] 1.2 - 1.5）、高血压（OR 1.6; 95% CI 1.2 - 2.0）和体重指数（OR 0.8/4.3 kg/m2; 95% CI 0.7 - 0.9）。TR的决定因素为年龄（OR 1.5/9.9岁; 95% CI 1.3 - 1.7）、体重指数（OR 0.7/4.3 kg/m2：95% CI 0.6 - 0.8）和女性（OR 1.2; 95% CI 1.0 - 1.6）。AR的决定因素为年龄（OR 2.3/9.9岁; 95% CI 2.0 - 2.7）和男性（OR 1.6; 95% CI 1.2 - 2.1）。相当比例的健康男性和女性有彩色多普勒超声心动图可检测到瓣膜返流。这些数据提供了基于人群的估计值，用于与服用厌食药物的患者进行比较。(C)1999年由Excerpta Medico，Inc.
Little information is available on the prevalence and determinants of valvular regurgitation in the general population. This study sought to assess the prevalence and clinical determinants of mitral (MR), tricuspid (TR), and aortic (AR) regurgitation in a population-based cohort. Color Doppler echocardiography was performed in 1,696 men and 1,893 women (aged 54 +/- 10 years) attending a routine examination at the Framingham Study. After excluding technically poor echocardiograms, MR, TR, and AR were qualitatively graded from trace to severe. Multiple logistic regression analysis was used to examine the association of clinical variables with MR and TR (more than or equal to mild severity) and AR (more than or equal to trace severity). MR and TR of more than or equal to mild severity was seen In 19.0% and 14.8% of men and 19.1% and 18.4% of women, respectively, and AR of more than or equal to trace severity in 13.0% of men and 8.5% of women. The clinical determinants of MR were age (odds ratio [OR] 1.3/9.9 years, 95% confidence interval [CI] 1.2 to 1.5), hypertension (OR 1.6; 95% CI 1.2 to 2.0), and body mass index (OR 0.8/4.3 kg/m(2); 95% CI 0.7 to 0.9). The determinants of TR were age (OR 1.5/9.9 years; 95% CI 1.3 to 1.7), body mass index (OR 0.7/4.3 kg/m(2): 95% CI 0.6 to 0.8), and female gender (OR 1.2; 95% CI 1.0 to 1.6). The determinants of AR were age (OR 2.3/9.9 years; 95% CI 2.0 to 2.7) and male gender (OR 1.6; 95% CI 1.2 to 2.1). A substantial proportion of healthy men and women had detectable valvular regurgitation by color Doppler echocardiography. These data provide population-based estimates for comparison with patients taking anorectic drugs. (C) 1999 by Excerpta Medico, Inc.