Recent bioinspired applications of single-chain nanoparticles
Recent bioinspired applications of single-chain nanoparticles
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DOI：
10.1002/pi.5078
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发表时间：
2016-08-01
影响因子：
3.2
通讯作者：
Pomposo, Jose A.
中科院分区：
文献类型：
--
作者：
Latorre-Sanchez, Alejandro;Pomposo, Jose A.
单链纳米颗粒（SCNP）是通过单链压实构建的聚合物软纳米物体，被设想为构建未来智能生物功能纳米器件的通用构建块。根据其在溶液中的形态，SCNP 可分为 (i) 稀疏 SCNP，其形态类似于本质上无序的蛋白质，具有由柔性间隔物连接的局部致密区域，以及 (ii) 球状 SCNP，其形态更类似于天然致密蛋白质（即酶）中发现的形态。这篇小型评论的目的是强调 SCNP 最近的仿生应用，并深入了解这个快速发展领域的当前趋势。在简要介绍了用于构建 SCNP 的主要技术并清楚地描述了如何调整 SCNP 溶液中的形态之后，描述了使用 SCNP 作为结合蛋白模拟物、还原酶、氧化酶、醛缩酶、聚合酶和金属酶模拟物以及高效生物传感元件的最新示例。 (c) 2016年化学工业学会
Single-chain nanoparticles (SCNPs) are polymeric soft nano-objects constructed via individual chain compaction which are envisioned as versatile building blocks for the construction of future smart, biofunctional nanodevices. According to their morphology in solution, SCNPs can be classified as (i) sparse SCNPs resembling the morphology of intrinsically disordered proteins having local compact zones connected by flexible spacers and (ii) globular SCNPs having a morphology more akin to that found in native, compact proteins (i.e. enzymes). The objective of this mini-review is to highlight recent bioinspired applications of SCNPs and to give an insight into the current trends of this rapidly evolving field. After a brief introduction to the main techniques employed to construct SCNPs and a clear description of how to tune the morphology in solution of SCNPs, very recent examples of the use of SCNPs as binding protein mimics, reductase-, oxidase-, aldolase-, polymerase- enzyme and metalloenzyme mimics, as well as efficient biosensing elements are described. (c) 2016 Society of Chemical Industry