Response to Letter Regarding Article, "Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes: Phase II Results From the Pulmonary Artery Denervation-1 Study".
Response to Letter Regarding Article, "Hemodynamic, Functional, and Clinical Responses to Pulmonary Artery Denervation in Patients With Pulmonary Arterial Hypertension of Different Causes: Phase II Results From the Pulmonary Artery Denervation-1 Study".
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对有关文章“不同原因肺动脉高压患者对肺动脉去神经的血流动力学、功能和临床反应：肺动脉去神经-1 研究的 II 期结果”的回复。
DOI：
10.1161/circinterventions.115.003463
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chen SL
中科院分区：
文献类型：
--
作者：
Chen SL
正如我们在肺动脉失神经-1(PADN-I)研究中所描述的，3肺动脉高压靶向药物的停药是基于患者在接受这些靶向治疗数年后的临床和血流动力学测量。结果并不令人惊讶，主要是因为(1)大多数患者接受了数年的最大剂量药物治疗，但临床和血流动力学指标没有明显改善，这表明患者死亡的风险很高；(2)18例患者继发于左心衰竭的肺动脉高压(15例既往心肌梗死，3例扩张型心肌病)。我们已经意识到了这个死亡率；然而，由于我们的分析中没有对照组，所以现在就质疑这个数字与药物相比太高还为时过早。同样，一些靶向药物对肺动脉高压患者是有毒的。
As we described in Pulmonary Artery Denervation-1 (PADN-I) study, 3 the withdrawal of target drugs for pulmonary arterial hypertension was based on the clinical and hemodynamic measurements when patients had taken these targeted therapies for several years. A reason seemed to be ethical.In terms of 12% all-cause mortality at 1-year follow-up after pulmonary artery denervation, the result is not surprising mainly because (1) most patients had been put on maximal medication for several years, without significant improvement in clinical and hemodynamic variables, indicating that patients were at high risk of death,(2) 18 patients had pulmonary hypertension secondary to left heart failure (15 with previous myocardial infarction and 3 with dilated cardiomyopathy). We have realized this number of mortality; however, it is too earlier to question that this number is too high when compared with medication because of no control group in our analysis. Again, some target drugs are toxic to patients with pulmonary arterial hypertension.
影响因子：
24
作者：
Chen, Shao-Liang;Zhang, Feng-Fu;Stone, Gregg W.
通讯作者：
Stone, Gregg W.