Tumor purity as a prognosis and immunotherapy relevant feature in gastric cancer.
Tumor purity as a prognosis and immunotherapy relevant feature in gastric cancer.
复制标题
肿瘤纯度作为胃癌的预后和免疫治疗相关特征
DOI：
10.1002/cam4.3505
复制
发表时间：
2020-12
期刊：
影响因子：
4
通讯作者：
Guo W
中科院分区：
文献类型：
--
作者：
Gong Z;Zhang J;Guo W
越来越多的研究表明肿瘤微环境（TME）在预测预后和治疗效果方面具有重要的临床病理意义。肿瘤纯度是指肿瘤组织中癌细胞所占的比例，反映了TME的特征。然而，目前的胃癌分期和预后预测系统很少关注TME。因此，我们开展了本研究，探讨肿瘤纯度在GC中的作用。我们回顾性收集了来自四个公共数据集（n = 1340）的临床和转录组学数据，GSE 15459，GSE 26253，GSE 62254和癌症基因组图谱（TCGA）。来自复旦大学附属肿瘤医院的34例胃癌患者作为一个独立的验证组。通过计算方法测量肿瘤纯度。低肿瘤纯度与不良预后、上调EMT和干性途径、TcB、M1和M2巨噬细胞更多浸润以及招募免疫抑制细胞的各种免疫检查点和趋化因子的更高表达水平相关。我们的研究表明，GC中的低肿瘤纯度与不良预后和免疫逃避表型相关。进一步研究胃癌的肿瘤纯度有助于预后预测和治疗策略的制定。
Tumor microenvironment (TME) has been illustrated their clinic pathological significance in predicting outcomes and therapeutic efficacy by more and more studies. Tumor purity, which reflects the features of TME, is defined as the proportion of cancer cell in the tumor tissue. However, the current staging and prognostic prediction system in gastric cancer (GC) paid little attention to TME. Therefore, we carried out the study to explore the role of tumor purity in GC. We retrospectively collected the clinical and transcriptomic data from four public data sets (n = 1340), GSE15459, GSE26253, GSE62254, and The Cancer Genome Atlas (TCGA). About 34 GC patients from Fudan University Shanghai Cancer Center (FUSCC) were assigned as an independent validation group. Tumor purity was measured by a computational method. Low tumor purity was associated with unfavorable prognosis, upregulated EMT and stemness pathways, more infiltrating of Tregs, M1 and M2 macrophages and a higher expression level of various immune checkpoints and chemokines recruiting immune suppressive cells. Our study indicates low tumor purity in GC was associated with unfavorable prognosis and immune‐evasion phenotype. Further investigations toward tumor purity in GC may contribute to prognosis prediction and the decision of therapy strategies.
登录
查看更多内容
影响因子：
4.8
作者：
Chang, Qing;Bournazou, Eirini;Bromberg, Jacqueline
通讯作者：
Bromberg, Jacqueline
低肿瘤纯度与结肠癌的不良预后、重突变负担和强烈的免疫表型相关
影响因子：
3.3
作者：
Mao Y;Feng Q;Zheng P;Yang L;Liu T;Xu Y;Zhu D;Chang W;Ji M;Ren L;Wei Y;He G;Xu J
通讯作者：
Xu J
DOI：
10.1093/bioinformatics/bty043
发表时间：
2018-06-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.6
作者：
Chen, Zong-Lin;Qin, Lu;Liu, Bo
通讯作者：
Liu, Bo
影响因子：
4.7
作者：
Yang, Zihui;Li, Huan;Yang, Xinjie
通讯作者：
Yang, Xinjie