The correlation between serum AMH and HOMA-IR among PCOS phenotypes.
The correlation between serum AMH and HOMA-IR among PCOS phenotypes.
复制标题
DOI：
10.1186/s13104-018-3207-y
复制
发表时间：
2018-02-09
影响因子：
1.8
通讯作者：
Hestiantoro A
中科院分区：
文献类型：
--
作者：
Wiweko B;Indra I;Susanto C;Natadisastra M;Hestiantoro A
多囊卵巢综合征(PCOS)是影响育龄妇女的最常见的内分泌疾病之一。内分泌紊乱之一是高胰岛素血症，与PCOS的严重程度相对应。然而，PCOS的发病机制尚不完全清楚，但有一种学说认为，抗苗勒氏激素(AMH)是影响PCOS严重程度的因素之一。然而，在多囊卵巢综合征患者中，特别是在印度尼西亚，AMH水平与胰岛素抵抗的发生率之间没有明显的相关性。这是一项涉及18-35岁育龄妇女的横断面研究。受试者在2011至2014年间在Cipto Mangunkusumo医生综合医院连续招募。根据2003年鹿特丹标准诊断的多囊卵巢综合征妇女被分为四种不同的多囊卵巢综合征表型。随后，用SPSS11.0软件对血清AMH和HOMA-IR水平进行了测量和相关性检验。125名PCOS患者参加了一项为期3年的研究。表型1(无排卵、高雄激素血症和多囊卵巢)显示出最高水平的AMH和HOMA-IR，其水平随病情严重程度而降低(P<0.005)。即使在多变量分析中调整了BMI后，AMH和HOMA-IR之间的正相关性仍然存在。血清AMH水平与HOMA IR水平呈正相关。血清AMH和HOMA IR水平在四种PCOS表型之间有显著差异；表型1的水平最高。
Polycystic ovarian syndrome (PCOS) is known to be one of the most prevalent endocrine disorders affecting reproductive age women. One of the endocrine disorder is hyperinsulinemia, which corresponds with the severity of PCOS. However, the pathogenesis of PCOS is not fully understood, but one theory of anti-mullerian hormone (AMH) has been proposed as one of the factor related to the degree of severity of PCOS. However, there are no clear correlation between levels of AMH with the incidence of insulin resistance in PCOS patients especially in Indonesia. This is a cross-sectional study involving reproductive age women aged 18–35 years. Subjects were recruited consecutively at Dr. Cipto Mangunkusumo General Hospital between 2011 until 2014. PCOS women diagnosed using 2003 Rotterdam criteria were categorized into four different PCOS phenotypes. Subsequently, serum level of AMH and HOMA-IR was measured and evaluated with correlation tests performed using SPSS 11.0 A total of 125 PCOS patients were included in a study conducted within a 3-year period. Phenotype 1 (anovulation, hyperandrogenism, and polycystic ovaries) shows the highest levels of AMH and HOMA-IR, which decreases in accordance to severity level (p < 0.005). The positive correlation between AMH and HOMA-IR persisted even after adjusting for BMI in multivariate analysis. There was a positive correlation between serum AMH and HOMA IR levels. Serum AMH and HOMA IR levels were significantly different across the four PCOS phenotypes; with the highest values were present with phenotype 1.