Aging and the role of the HPA axis and rhythm in sleep and memory-consolidation
Aging and the role of the HPA axis and rhythm in sleep and memory-consolidation
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DOI：
10.1176/appi.ajgp.13.5.344
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发表时间：
2005-05-01
影响因子：
7.2
通讯作者：
Schatzberg, AF
中科院分区：
文献类型：
--
作者：
Buckley, TM;Schatzberg, AF
下丘脑-垂体-肾上腺（HPA）轴的变化及其随年龄增长的节律对睡眠有着有趣的影响。在此，作者回顾了与正常衰老相关的睡眠和HPA变化，并指出它们如何随时间变化的相似性。作者还特别讨论了睡眠对陈述性记忆巩固的影响。这一集中的综述表明，一些陈述性记忆功能障碍与正常老化，并可能程序性记忆功能障碍，可能是部分可逆的方法，以增加慢波睡眠（SWS）。此外，降低夜间促肾上腺皮质激素释放激素和皮质醇最低点并增强SWS的药物可能提供操纵HPA轴/节律并改善睡眠和记忆的潜在方法。在这方面，作者提出，直接作用于HPA轴的药物（例如，例如，在一个实施例中，盐皮质激素激动剂）对于改善睡眠和睡眠期间的陈述性记忆巩固可能非常有用。
Changes in the hypothalamo-pituitary-adrenal (HPA) axis and its rhythm with aging have interesting implications for sleep. Herein, the authors review sleep and HPA changes associated with normal aging and point out the similarities in how they change over time. The authors also discuss the effects of sleep on declarative memory consolidation, in particular. This focused review suggests that some of the declarative memory dysfunction with normal aging, and possibly procedural memory dysfunction, may be partially reversible by instituting methods to augment slow-wave sleep (SWS). Also, agents that decrease nocturnal corticotropin-releasing hormone and the cortisol nadir and enhance SWS may offer potential ways to manipulate the HPA axis/ rhythm and improve sleep and memory. In this regard, the authors propose that drugs that act directly on the HPA axis ( e. g., mineralocorticoid agonists) may be potentially quite useful for improving both sleep and declarative memory consolidation during sleep.