Prediction of long-term survival in patients with metastatic gastrointestinal stromal tumor: analysis of a large, single-institution cohort
Prediction of long-term survival in patients with metastatic gastrointestinal stromal tumor: analysis of a large, single-institution cohort
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DOI：
10.1080/0284186x.2017.1330555
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发表时间：
2017-01-01
期刊：
影响因子：
3.1
通讯作者：
Boye, Kjetil
中科院分区：
文献类型：
--
作者：
Hompland, Ivar;Bruland, Oyvind Sverre;Boye, Kjetil
背景：一部分转移性GIST患者成为长期幸存者，更精确的预后预测可以改善临床决策。材料和方法：从奥斯陆大学医院的肉瘤数据库中确定了1995年至2013年诊断为转移性GIST的133例患者。在数据库中前瞻性登记的临床数据补充了对医疗记录的回顾性审查。采用Kaplan-Meier曲线、log-rank检验、单因素和多因素Cox回归分析对影响生存率的因素进行分析。结果：115例转移性GIST患者被纳入最终研究队列。中位总生存期（OS）为6.9年（95% CI 5.6-8.3）。在单因素分析中，与长期生存相关的因素是良好的基线状态(ECOG 1; p
Background: A subset of patients with metastatic GIST become long-term survivors, and a more precise prediction of outcome could improve clinical decision-making.Material and methods: One-hundred and thirty-three patients diagnosed with metastatic GIST from 1995 to 2013 were identified from the sarcoma database at Oslo University Hospital. Clinical data prospectively registered in the database were supplemented with retrospective review of medical records. Factors associated with survival were analyzed using Kaplan-Meier curves, log-rank test, univariate and multivariate Cox regression analyses.Results: One-hundred and fifteen patients with metastatic GIST were included in the final study cohort. Median overall survival (OS) was 6.9 years (95% CI 5.6-8.3). Factors associated with long-term survival in univariate analysis were good baseline performance status (ECOG 1; p