THE ROLE OF MULTIMODALITY THERAPY IN SOFT-TISSUE SARCOMA
THE ROLE OF MULTIMODALITY THERAPY IN SOFT-TISSUE SARCOMA
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多模式治疗在软组织肉瘤中的作用
DOI：
10.1097/00000658-199109000-00015
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发表时间：
1991-09-01
影响因子：
9
通讯作者：
HAJDU, SI
中科院分区：
文献类型：
--
作者：
BRENNAN, MF;CASPER, ES;HAJDU, SI
软组织肉瘤是罕见的恶性肿瘤。描述了一个机构在 8 年时间内开发的前瞻性数据库，其中包含 1600 多名患有这些肿瘤的患者。最常见的发生部位是四肢，但也可以发生在身体的任何软组织中。脂肪肉瘤和平滑肌肉瘤是最常见的组织病理学病症。复发和生存的预后因素包括部位、组织病理学、大小、分级和切除的充分性。一项关于近距离放射治疗技术使用辅助放射治疗四肢病变的前瞻性随机试验显示，局部复发率有所下降，但对生存没有影响。未随机参加试验的符合条件的患者，无论是否接受辅助放疗，局部复发或生存率均无差异。
Soft-tissue sarcomas are uncommon malignancies. The development during a period of 8 years, in one institution, of a prospective data base incorporating more than 1600 patients with these tumors is described. The most common sites for occurrence are the extremities, but they can occur in any of the soft tissues of the body. Liposarcoma and leiomyosarcoma are the most common histopathologic conditions identified. Prognostic factors for both recurrence and survival include site, histopathology, size, grade, and adequacy of resection. A prospective randomized trial of the use of adjuvant radiation by the brachytherapy technique in extremity lesions has shown a decrease in local recurrence, but no impact on survival. Eligible patients not randomized to the trial show no difference in local recurrence or survival, regardless of whether they received adjuvant radiation.