Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men.
Socioeconomic Status, Financial Strain, and Leukocyte Telomere Length in a Sample of African American Midlife Men.
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非裔美国中年男性样本的社会经济地位、财务压力和白细胞端粒长度。
DOI：
10.1007/s40615-017-0388-3
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发表时间：
2018
影响因子：
3.9
通讯作者：
Chae,DavidH
中科院分区：
文献类型：
--
作者：
Schrock,JoshuaM;Adler,NancyE;Epel,ElissaS;Nuru-Jeter,AmaniM;Lin,Jue;Blackburn,ElizabethH;Taylor,RobertJoseph;Chae,DavidH
在美国，与白人男性相比，非洲裔美国男性的老龄化相关健康状况较差，部分原因是种族之间的社会经济差异。随着白细胞端粒长度（LTL）的缩短，非裔美国男性更多地暴露于社会经济菌株可能会在细胞水平上对健康和衰老产生不利影响。本研究考察了非裔美国中年男性的社会经济因素与LTL之间的关系，这是一个健康和社会经济地位异质性特别明显的生命历程阶段。方法采用多项逻辑回归，研究了92名年龄在30至50岁之间的非裔美国男性中SES和LTL的多个测量值之间的关系。结果较大的财务压力报告与较高的短期LTL与中等LTL的几率相关（优势比(OR)=2.21,p= 0.03）。较高的收入与较低的短端粒与中端粒的几率相关（OR=0.97,p= 0.04）。探索性分析显示，受教育程度与就业状况之间存在显著的相互作用（χ2= 4.07,p= 0.04），未就业人群中，受教育程度越高，端粒越短的几率越低（OR=0.10,p= 0.040）。结论与社会经济逆境多维度相关的细胞衰老可能导致非裔美国男性衰老相关健康结果不佳。财务困难的主观评价可能独立于SES的客观维度影响LTL。自我评价成功地完成了传统的男性性别角色，包括成为经济提供者，可能是非裔美国男性身份的一个特别突出的方面，并对该人群的细胞衰老有影响。
BackgroundAfrican American men in the USA experience poorer aging-related health outcomes compared to their White counterparts, partially due to socioeconomic disparities along racial lines. Greater exposure to socioeconomic strains among African American men may adversely impact health and aging at the cellular level, as indexed by shorter leukocyte telomere length (LTL). This study examined associations between socioeconomic factors and LTL among African American men in midlife, a life course stage when heterogeneity in both health and socioeconomic status are particularly pronounced.MethodsUsing multinomial logistic regression, we examined associations between multiple measures of SES and tertiles of LTL in a sample of 92 African American men between 30 to 50 years of age.ResultsReports of greater financial strain were associated with higher odds of short versus medium LTL (odds ratio (OR)=2.21,p= 0.03). Higher income was associated with lower odds of short versus medium telomeres (OR=0.97,p= 0.04). Exploratory analyses revealed a significant interaction between educational attainment and employment status (χ2= 4.07,p= 0.04), with greater education associated with lower odds of short versus long telomeres only among those not employed (OR=0.10,p= 0.040).ConclusionCellular aging associated with multiple dimensions of socioeconomic adversity may contribute to poor aging-related health outcomes among African American men. Subjective appraisal of financial difficulty may impact LTL independently of objective dimensions of SES. Self-appraised success in fulfilling traditionally masculine gender roles, including being an economic provider, may be a particularly salient aspect of identity for African American men and have implications for cellular aging in this population.