Naloxone's effect on meal microstructure of sucrose and cornstarch diets
Naloxone's effect on meal microstructure of sucrose and cornstarch diets
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DOI：
10.1152/ajpregu.2001.281.5.r1605
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发表时间：
2001-11-01
影响因子：
2.8
通讯作者：
Levine, AS
中科院分区：
文献类型：
--
作者：
Glass, MJ;Grace, MK;Levine, AS
阿片受体拮抗剂纳洛酮减少高蔗糖饮食的消耗，但不减少能量限制大鼠的玉米淀粉饮食摄入量。喂食蔗糖的老鼠进食率要高得多，比喂玉米淀粉的老鼠消耗更多的食物。我们使用自动称重系统检测了食用高蔗糖或高玉米淀粉饮食的限食大鼠的膳食微结构。与喂食玉米淀粉的老鼠相比，喂蔗糖的老鼠在第一顿饭中的进食率更高(分别为0.34克/分钟和0.20克/分钟)。然而，纳洛酮并没有降低两组的进食率。纳洛酮通过缩短进餐时间减少了两个节食组的第一餐的大小。纳洛酮的厌食作用在喂食蔗糖的大鼠中更强。这些结果表明，纳洛酮对蔗糖饮食消耗的增强厌食作用不是“速率依赖的”。纳洛酮的厌食作用可能受两种条件的调节，食物的感官特性和动物的能量状态。因此，在能量受限的蔗糖喂养的大鼠中，纳洛酮的厌食效力的提高可能反映了对神经系统的作用，这些神经系统介导了味觉和/或消化后信号。
The opioid receptor antagonist naloxone decreases consumption of high-sucrose diets but does not reduce cornstarch diet intake in energy-restricted rats. Sucrose-fed rats eat at a much higher rate, consuming more food than cornstarch-fed rats. We examined meal microstructure using an automated weighing system in food-restricted rats eating either a high-sucrose or high-cornstarch diet. Sucrose-fed rats exhibited a higher rate of eating during their first meal compared with cornstarch-fed rats (0.34 vs. 0.20 g/min, respectively). However, naloxone did not reduce eating rate in either group. Naloxone decreased the size of the first meal in both diet groups by shortening the length of the meal. Naloxone's anorectic effect was more potent in the sucrose-fed rats. These results indicate that naloxone's heightened anorectic effect on sucrose diet consumption is not "rate dependent." Naloxone's anorectic actions may be modulated by two conditions, the sensory properties of food and the energy state of the animal. Thus the elevated anorectic potency of naloxone in energy-restricted sucrose-fed rats may reflect actions on neural systems that mediate orosensory and/or postingestive signals.