Glucocorticoid receptors in PVN: interactions with NE, NPY, and Gal in relation to feeding.
Glucocorticoid receptors in PVN: interactions with NE, NPY, and Gal in relation to feeding.
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PVN 中的糖皮质激素受体：与进食相关的 NE、NPY 和 Gal 的相互作用。
DOI：
10.1152/ajpendo.1993.265.5.e794
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Leibowitz,SF
中科院分区：
文献类型：
--
作者：
Tempel,DL;Leibowitz,SF
去甲肾上腺素（NE）和神经肽Y（NPY）注射到室旁核（PVN）后加强碳水化合物的摄入，而甘丙肽（Gal）注射加强脂肪的摄入。本研究探讨了这些神经化学诱导的摄食行为和肾上腺皮质类固醇在PVN内的局部作用之间的关系。结果表明，PVN NE和NPY诱导的碳水化合物的摄入被肾上腺切除术（ADX）和局部PVN植入II型受体拮抗剂RU-486废除。响应PVN NE或NPY注射的碳水化合物摄入不受I型拮抗剂RU-28318的影响。相比之下，PVN Gal注射对脂肪摄入的刺激作用不受手术ADX或PVN施用RU-486或RU-28318的影响，表明Gal对脂肪摄入的刺激作用独立于皮质酮（Cort）和PVN I型或II型类固醇受体而发生。它的结论是，内源性Cort有一个许可的影响，引起的NE和NPY在PVN的碳水化合物喂养反应，这种相互作用是由II型糖皮质激素受体介导的在这个核。
Norepinephrine (NE) and neuropeptide Y (NPY) potentiate carbohydrate ingestion after injection into the paraventricular nucleus (PVN), whereas injection of galanin (Gal) potentiates fat intake. The present study examines the relation between these neurochemically induced feeding behaviors and the adrenal steroids acting locally within the PVN. Results demonstrate that PVN NE- and NPY-induced carbohydrate intake is abolished by adrenalectomy surgery (ADX) and by local PVN implants of the type II receptor antagonist RU-486. Carbohydrate intake in response to PVN NE or NPY injection is unaffected by the type I antagonist RU-28318. In contrast, the stimulatory effect of PVN Gal injection on fat intake is unchanged by surgical ADX or by PVN administration of RU-486 or RU-28318, suggesting that the stimulatory action of Gal on fat ingestion occurs independently of corticosterone (Cort) and of PVN type I or type II steroid receptors. It is concluded that endogenous Cort has a permissive effect on the carbohydrate feeding responses elicited by NE and NPY in the PVN and that this interaction is mediated by type II glucocorticoid receptors within this nucleus.