Inhibition of denture plaque deposition on complete dentures by 2-methacryloyloxyethyl phosphorylcholine polymer coating: A clinical study
Inhibition of denture plaque deposition on complete dentures by 2-methacryloyloxyethyl phosphorylcholine polymer coating: A clinical study
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DOI：
10.1016/j.prosdent.2017.02.012
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发表时间：
2018-01-01
影响因子：
4.6
通讯作者：
Baba, Kazuyoshi
中科院分区：
文献类型：
--
作者：
Ikeya, Kenji;Iwasa, Fuminori;Baba, Kazuyoshi
陈述问题。牙菌斑相关感染被认为是老年人群中严重牙科和医疗并发症的来源。需要管理此问题的方法。目的。目的2-甲基丙烯酰氧乙基义齿。本临床研究的目的是评价磷酸胆碱聚合物PMBPAz对全口义齿菌斑沉积的影响。研究方案获得昭和大学伦理委员会批准（#2013-013）。11名上颌全口义齿患者参加了本研究。用PMBPAz处理他们的义齿，并通过在义齿使用2周后用亚甲蓝染色义齿表面来评估义齿菌斑积聚的量。重复相同的程序，以评估作为对照的原始义齿表面。使用数码相机捕获染色义齿表面的图像，并计算粘膜和抛光表面的染色面积百分比（量化为基于像素的密度）占整个义齿面积（菌斑指数百分比）。为了定量义齿上的生物膜，通过超声振动分离义齿菌斑生物膜，重悬于稀释剂中，并用酶标仪在620 nm的光密度下测量。PMBPAz治疗对这些变量的影响采用ANOVA（α =.05）进行统计学分析。在对照义齿的粘膜表面上，菌斑指数的平均+/- SD百分比为40.7% +/- 19.9%，在抛光表面上为28.0% +/- 16.8%。PMBPAz处理的义齿的平均菌斑指数百分比在粘膜表面显著降低至17.4% ± 12.0%（P
Statement of problem. Denture plaque-associated infections are regarded as a source of serious dental and medical complications in the elderly population. Methods of managing this problem are needed.Purpose. The purpose 2-methacryloyloxyethyl dentures. of this clinical study was to evaluate the effects of treatment with a phosphorylcholine polymer, PMBPAz, on plaque deposition in complete dentures.Material and methods. The study protocol was approved by the Ethics Committee of Showa University (#2013-013). Eleven individuals with maxillary complete dentures participated in this study. Their dentures were treated with PMBPAz, and the amount of denture plaque accumulation was evaluated by staining the denture surfaces with methylene blue after 2 weeks of denture usage. The same procedures were repeated to evaluate the original denture surfaces as a control. The image of the stained denture surface was captured using a digital camera, and the percentage of stained area, quantified as a pixel-based density, of the whole denture area (percentage of plaque index) was calculated for the mucosal and polished surfaces. To quantify the biofilm on the dentures, denture plaque biofilm was detached by ultrasonic vibration, resuspended in diluent, and measured with a microplate reader at an optical density of 620 nm. The effects of PMBPAz treatment on these variables were statistically analyzed with ANOVA (alpha=.05).Results. The mean +/- SD percentage of plaque index was 40.7% +/- 19.9% on the mucosal surfaces and 28.0% +/- 16.8% on the polished surfaces of the control denture. The mean percentage of plaque index of PMBPAz-treated dentures significantly decreased to 17.4%% +/- 12.0% on the mucosal surfaces (P