Antibody-independent binding of complement component C1q by Legionella pneumophila.
Antibody-independent binding of complement component C1q by Legionella pneumophila.
复制标题
嗜肺军团菌与补体成分 C1q 的抗体独立结合。
DOI：
10.1128/iai.63.12.4939-4943.1995
复制
发表时间：
1995
影响因子：
3.1
通讯作者：
Schultz,DR
中科院分区：
文献类型：
--
作者：
Mintz,CS;Arnold,PI;Johnson,W;Schultz,DR
嗜肺军团菌Philadelphia 1在去除经典途径组分C1q或替代途径组分因子B的正常人血清中孵育导致补体系统激活。实验集中在补体激活的经典途径的作用，发现军团菌结合C1q独立的抗体。L.嗜肺菌主要外膜蛋白而不是血清1型脂多糖独立于抗体结合C1q。这表明L. pneumophila可以导致正常人血清中经典途径的激活，并且主要外膜蛋白可能是L.嗜肺细胞表面。
Incubation of Legionella pneumophila Philadelphia 1 in normal human serum depleted of either classical-pathway component C1q or alternative-pathway component factor B resulted in activation of the complement system. Experiments focused on the role of the classical pathway in complement activation revealed that legionellae bound C1q independently of antibody. Purified preparations of L. pneumophila major outer membrane protein but not serogroup 1 lipopolysaccharide bound C1q independently of antibody. This suggests that antibody-independent binding of C1q by L. pneumophila can result in activation of the classical pathway in normal human serum and that major outer membrane protein may be a C1q acceptor on the L. pneumophila cell surface.