Coordination-Induced Assembly of Coordination Polymer Submicrospheres: Promising Antibacterial and in Vitro Anticancer Activities
Coordination-Induced Assembly of Coordination Polymer Submicrospheres: Promising Antibacterial and in Vitro Anticancer Activities
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配位聚合物亚微球的配位诱导组装：有前景的抗菌和体外抗癌活性
DOI：
10.1021/cg3006162
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发表时间：
2012-07-01
影响因子：
3.8
通讯作者：
Wang, Zhilin
中科院分区：
文献类型：
--
作者：
Wang, Kuaibing;Ma, Xiaoyan;Wang, Zhilin
通过过渡金属离子与3，5-二(吡啶-3-甲氨基)苯甲酸(L1)的水热反应，合成了亚微米级球形配位聚合物。最终配位聚合物的大小取决于反应物的浓度。在生长的多个阶段监测的扫描电子显微镜研究表明，配位诱导的形态从未配位的花状配体转变为球状配位聚合物颗粒。此外，发光和抗菌轮廓的变化与配位环境或所获得的配位聚合物样品的大小有关。此外，新合成的铜基聚合物粒子对三种选定的癌细胞株MCF-7、HeLa和NCI-H446具有较强的体外抗癌活性，因此可能成为未来新型金属抗癌药物。
Spheres-like coordination polymer architectures in submicro regimes have been synthesized from the hydrothermal reaction of transition metal ions and 3,5-bis(pyridin-3-ylmethylamino)benzoic acid (L1). The size of the final coordination polymer was dependent on the concentrations of reactants. Scanning electron microscopy studies monitored at numerous stages of growth reveal that coordination-induced morphology changes from uncoordinated flowerlike ligands to sphere-like coordination polymer particles. Moreover, variations of luminescent and antibacterial profiles are associated with coordination environments or the size of as-obtained coordination polymer samples. In addition, the newly synthesized Cu-based polymer particles may act as novel metal-based anticancer drugs in the future because of their potent in vitro anticancer activities against three chosen cancer lines MCF-7, HeLa, and NCI-H446.