Repurposing staples for viruses: applying peptide design to RSV prophylaxis.
Repurposing staples for viruses: applying peptide design to RSV prophylaxis.
复制标题
病毒主食的重新利用：将肽设计应用于 RSV 预防。
DOI：
10.1172/jci75797
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Dermody,TerenceS
中科院分区：
文献类型：
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作者：
Katen,SarahP;Dermody,TerenceS
Respiratory syncytial virus (RSV) is responsible for lower respiratory tract infections and annually results in 200,000 deaths worldwide. Despite the burden of RSV-associated disease, treatments and preventative measures are limited. In this issue ofJCI, Bird and colleagues describe their work using a peptide stapling technique that allowed synthesis of a stable peptide mimic of a portion of the RSV fusion protein. Pretreatment of cells with the stable peptide effectively blocked virus entry. When introduced into mice prior to RSV exposure, the peptide produced a substantial prophylactic effect. This work provides a new way forward in RSV prevention.
