EFFECT OF HYDROXYUREA ON RIBONUCLEOTIDE REDUCTASE
EFFECT OF HYDROXYUREA ON RIBONUCLEOTIDE REDUCTASE
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DOI：
10.1016/0006-291x(68)90266-0
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发表时间：
1968-01-01
影响因子：
3.1
通讯作者：
ELFORD, HL
中科院分区：
文献类型：
--
作者：
ELFORD, HL
Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis and cell proliferation without affecting RNA and protein synthesis (Gale, 1964; Young and Hodas, 19641 Yarbro et al--0'1965 Rosenbranz and Levy, 1965). A variety of evidence, primarily in vivo, has accumulated which suggests that the mode of action of hydroxyurea is the inhibition of the conversion of ribonucleotides to deoxyribonucleotides, a critical step in DNA synthesis (Frenkel et al., 1964; Adams and Lindsay, 1967; Frenkel and Arthur, 1967; Elfora, 1967). It was decided to investigate the direct effect of hydroxyurea on a completely in vitro ribonucleotide reduction system isolated from three of the--most thoroughly studied deoxynucleotide synthesizing systems, Escherichia g, Lactobacillus leichmannii, and Novikoff hepatoma rat tumor. In addition, the effect of hydroxyurea on several animal ribonucleotide reduction systems was studied.
