A CYCLIC-3',5'-ADENOSINE MONOPHOSPHATE DEPENDENT PROTEIN KINASE FROM ADRENAL CORTEX - COMPARISON WITH A CYCLIC AMP BINDING PROTEIN
A CYCLIC-3',5'-ADENOSINE MONOPHOSPHATE DEPENDENT PROTEIN KINASE FROM ADRENAL CORTEX - COMPARISON WITH A CYCLIC AMP BINDING PROTEIN
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DOI：
10.1016/0006-291x(70)90581-4
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发表时间：
1970-01-01
影响因子：
3.1
通讯作者：
GARREN, LD
中科院分区：
文献类型：
--
作者：
GILL, GN;GARREN, LD
已在肾上腺皮质组织中鉴定出环AMP活化蛋白激酶。这种酶的K和核苷酸特异性类似于肾上腺皮质蛋白的K和核苷酸特异性，其特异性结合环AMP。初始纯化程序，导致在200倍纯化的结合蛋白和50倍纯化的蛋白激酶。虽然这两种活动的部分分离，这两种蛋白质的功能相互作用的建议。
A cyclic AMP activated protein kinase has been identified in adrenal cortical tissue. The Kmand nucleotide specificity of this enzyme resemble the Kaand nucleotide specificity of the adrenal cortical protein which specifically binds cyclic AMP. Initial purification procedures which result in a 200-fold purification of the binding protein and a 50-fold purification of the protein kinase are presented. Though a partial separation of these two activities is achieved, a functional interaction of these two proteins is suggested.