Adhere, Degrade, and Move: The Three-Step Model of Invasion.
Adhere, Degrade, and Move: The Three-Step Model of Invasion.
复制标题
DOI：
10.1158/0008-5472.can-16-1297
复制
发表时间：
2016-06-01
期刊：
影响因子：
11.2
通讯作者：
Liotta LA
中科院分区：
文献类型：
--
作者：
Liotta LA
1975-1986年期间的实验工作揭示了细胞外基质（ECM）在肿瘤细胞侵袭和转移中的至关重要性，并最终提出了侵袭的三步假说。第一步是肿瘤细胞附着到ECM上。第二步是ECM的蛋白水解降解，由推进突出的富含肌动蛋白的伪足引起。第三步是肿瘤细胞体通过重塑基质的迁移。这种机制方案被广泛接受，并继续产生与入侵细胞内外的大量分子相关的见解，这些分子在三个步骤中的每一个中都发挥作用。了解肿瘤细胞与ECM的相互作用在临床上从未如此重要。ECM不仅仅是一个被动的机械支架。相反，ECM是肿瘤和生理侵袭的积极参与者，并且充当信息高速公路、免疫避难所和支持肿瘤生长和耐药性的储存库（Cancer Res; 76（11）; 3115-7）。©2016 AACR.See related article by Liotta，Cancer Res 1986;46：1- 7. Visit theCancer Research 75 thAnniversary时间轴.
Experimental work during the period 1975–1986 revealed the crucial importance of the extracellular matrix (ECM) in tumor cell invasion and metastasis, and culminated in the three-step hypothesis of invasion. The first step is tumor cell attachment to the ECM. The second step is proteolytic degradation of the ECM, led by advancing protruding actin-rich pseudopods. The third step is migration of the tumor cell body through the remodeled matrix. This mechanistic scheme is widely accepted and continues to generate insights related to the large number of molecules, inside and outside invading cells, which all play a role in each of the three steps. Understanding the interaction of the tumor cells with the ECM has never been more clinically important. The ECM is not just a passive mechanical scaffold. Instead, the ECM is an active participant in neoplastic and physiologic invasion, and acts as an information highway, an immune sanctuary, and a storage depot supporting tumor growth and drug resistance.Cancer Res; 76(11); 3115–7. ©2016 AACR.See related article by Liotta, Cancer Res 1986;46:1–7.Visit theCancer Research75thAnniversary timeline.