A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols.
A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols.
复制标题
一种聚合物负载的脯氨酸基二胺催化剂，用于动力学拆分外消旋仲醇。
DOI：
10.1021/jo0013610
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Janda,KD
中科院分区：
文献类型：
--
作者：
Clapham,B;Cho,CW;Janda,KD
制备了用于动力学拆分仲醇外消旋混合物的聚合物支载的脯氨基二胺催化剂12。该催化剂不仅能有效地拆分多种不同的醇，而且还可以回收和重复使用几次，而不会损失活性或选择性。该催化剂与聚合物支持的隔离策略结合使用，产生了基本上纯净的已分解产物的混合物，可以使用闪光层析进行分离。
The preparation of polymer-supported proline-based diamine catalyst12for the kinetic resolution of racemic mixtures of secondary alcohols is described. Not only is the catalyst effective for the resolution of a host of different alcohols, it can also be recovered and reused several times without loss of either activity or selectivity. The catalyst has been used in conjunction with a polymer-supported sequestration strategy, giving rise to an essentially pure mixture of resolved products that can be separated using flash chromatography.