Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.
复制标题
DOI：
10.1016/j.phrs.2017.08.007
复制
发表时间：
2018-03
影响因子：
9.3
通讯作者：
Haqqi TM
中科院分区：
文献类型：
--
作者：
Khan NM;Haqqi TM
骨关节炎（OA）是最常见的关节疾病，也是全球中老年人群慢性残疾的主要原因。骨性关节炎的疾病修饰疗法的发展还处于起步阶段，很大程度上是因为人们对骨性关节炎发病机制中分子效应的调控机制知之甚少。最近的研究发现表观遗传事件是参与OA诱导和发展的分子参与者的关键调节因子。表观遗传机制包括DNA甲基化、非编码RNA和组蛋白修饰。这篇综述的目的是简要地强调软骨表观遗传学的最新进展和hdac（组蛋白去乙酰化酶）抑制剂在OA治疗管理中的潜力。我们总结了最近利用HDAC抑制剂作为抑制疾病进展和防止OA软骨破坏的潜在治疗方法的研究。hdac控制正常软骨发育和体内平衡，了解hdac抑制剂对疾病发病机制的影响是有趣的，因为它在影响整体软骨健康和体内平衡方面很重要。这些发现也为软骨疾病的病理生理学提供了新的线索，并提供了大量证据，证明hdac可能是OA的潜在新治疗靶点。
Osteoarthritis (OA) is the most common joint disease and the leading cause of chronic disability in middle-aged and older populations worldwide. The development of disease modifying therapy for OA is in its infancy largely because the regulatory mechanisms for the molecular effectors of OA pathogenesis are poorly understood. Recent studies identified epigenetic events as a critical regulator of molecular players involved in the induction and development of OA. Epigenetic mechanisms include DNA methylation, non-coding RNA and histone modifications. The aim of this review is to briefly highlight the recent advances in the epigenetics of cartilage and potential of HDACs (Histone deacetylases) inhibitors in the therapeutic management of OA. We summarize the recent studies utilizing HDAC inhibitors as potential therapeutics for inhibiting disease progression and preventing the cartilage destruction in OA. HDACs control normal cartilage development and homeostasis and understanding the impact of HDACs inhibitors on the disease pathogenesis is of interest because of its importance in affecting overall cartilage health and homeostasis. These findings also shed new light on cartilage disease pathophysiology and provide substantial evidence that HDACs may be potential novel therapeutic targets in OA.
登录
查看更多内容
组蛋白脱乙酰酶抑制激活 Nrf2 并预防骨关节炎
影响因子：
4.9
作者：
Cai D;Yin S;Yang J;Jiang Q;Cao W
通讯作者：
Cao W
影响因子：
3.7
作者：
Borgonio Cuadra VM;González-Huerta NC;Romero-Córdoba S;Hidalgo-Miranda A;Miranda-Duarte A
通讯作者：
Miranda-Duarte A
影响因子：
--
作者：
Gabay, Odile;Sanchez, Christelle;Dvir-Ginzberg, Mona;Gagarina, Viktoria;Zaal, Kristien J.;Song, Yingjie;He, Xiao Hong;McBurney, Michael W.
通讯作者：
McBurney, Michael W.
影响因子：
2.3
作者：
Díaz-Prado S;Cicione C;Muiños-López E;Hermida-Gómez T;Oreiro N;Fernández-López C;Blanco FJ
通讯作者：
Blanco FJ
影响因子：
5
作者：
Carpio, Lomeli R.;Westendorf, Jennifer J.
通讯作者：
Westendorf, Jennifer J.