Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands
Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: Preparation of FXR and PPAR ligands
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DOI：
10.1016/j.bmcl.2006.03.075
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发表时间：
2006-06-15
影响因子：
2.7
通讯作者：
Hashimoto, Yuichi
中科院分区：
文献类型：
--
作者：
Kainuma, Masahiko;Kasuga, Jun-ichi;Hashimoto, Yuichi
通过使用二苯甲烷骨架作为类固醇骨架的替代品，获得了新型、有效的法尼醇 X 受体 (FXR) 和过氧化物酶体增殖物激活受体 α (PPAR α) 激动剂。 (c) 2006 Elsevier Ltd. 保留所有权利。
Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPAR alpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton. (c) 2006 Elsevier Ltd. All rights reserved.