Sex-specific differences in white matter microvascular integrity after ischaemic stroke
Sex-specific differences in white matter microvascular integrity after ischaemic stroke
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DOI：
10.1136/svn-2019-000268
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发表时间：
2019-12-01
影响因子：
5.9
通讯作者：
Rost, Natalia S.
中科院分区：
文献类型：
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作者：
Etherton, Mark R.;Wu, Ona;Rost, Natalia S.
背景和目的尽管根据合并症和治疗方法的差异进行了调整，但女性缺血性中风后的功能结果较差。白质微血管完整性是缺血性中风后长期功能结果不佳的危险因素之一。本研究的目的是表征急性缺血性中风个体微血管完整性的性别特异性差异。方法对急性缺血性中风受试者进行回顾性分析，并使用弥散加权（DWI）和动态磁敏感对比增强（DSC）灌注加权成像在最后已知孔的 9 小时内获得脑 MRI。在急性梗塞的对侧半球中，使用 K-2 系数和表观扩散系数 (ADC) 值测量正常白质 (NAWM) 微血管完整性。 K-2 系数、DWI 体积和良好结果（90 天改良 Rankin 量表 (mRS) 评分）预测因子的回归分析
Background and purpose Functional outcomes after ischaemic stroke are worse in women, despite adjusting for differences in comorbidities and treatment approaches. White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke. The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted (DWI) and dynamic-susceptibility contrast-enhanced (DSC) perfusion-weighted imaging obtained within 9 hours of last known well was performed. In the hemisphere contralateral to the acute infarct, normal-appearing white matter (NAWM) microvascular integrity was measured using the K-2 coefficient and apparent diffusion coefficient (ADC) values. Regression analyses for predictors of K-2 coefficient, DWI volume and good outcome (90-day modified Rankin scale (mRS) score