Fractional anisotropy changes after several weeks of daily left high-frequency repetitive transcranial magnetic stimulation of the prefrontal cortex to treat major depression.
Fractional anisotropy changes after several weeks of daily left high-frequency repetitive transcranial magnetic stimulation of the prefrontal cortex to treat major depression.
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DOI：
10.1097/yct.0b013e3181e6317d
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
George MS
中科院分区：
文献类型：
--
作者：
Kozel FA;Johnson KA;Nahas Z;Nakonezny PA;Morgan PS;Anderson BS;Kose S;Li X;Lim KO;Trivedi MH;George MS
作为每天使用左颅磁刺激的假对照治疗试验的一部分，使用弥散张量成像（DTI）检查与4至6周治疗相关的大脑变化，以非侵入性地评估前额叶白质微观结构。左侧前额叶白质分数各向异性（FA）值的下降可能表明该区域受损。DTI分别在每日rTMS治疗前后4-6周进行。评估左、右前额叶白质（LPF-WM）与活动性rTMS和假性rTMS相关的平均FA水平。在rTMS前后，8名参与者（活动n=4，假n=4）获得了足够的图像。LPF-WM平均增加。混合模型显示出显著的治疗组×地区交互作用趋势（p=0.11）。此外，单纯区域效应（左侧前额叶WM与右侧前额叶WM）在活性rTMS组治疗后有显著性差异（p= 0.07），而在假性rTMS组无显著性差异（p= 0.88）。RTMS没有导致刺激一侧WM损伤的证据。DTI可能提供一种独特的方式来增加我们对rTMS作用机制的理解。
As part of a sham controlled treatment trial using daily left rTMS, brain changes associated with four to six weeks of treatment were examined using diffusion tensor imaging (DTI) in order to non-invasively evaluate prefrontal white matter microstructure. A decrease in fractional anisotropy (FA) values of the left prefrontal white matter could indicate damage to the region. DTI was performed prior to and after 4–6 weeks of daily rTMS treatments. Mean FA levels associated with active rTMS and sham rTMS for the right and left prefrontal white matter (LPF-WM) were assessed. Adequate images were acquired for eight participants (active n=4, sham n=4) before and after rTMS. A mean increase was found for the LPF-WM. The mixed model revealed a trend toward a significant Treatment Group × Region interaction effect (p=0.11). Further, simple Region effects (left prefrontal WM vs. right prefrontal WM) were at a trend toward significance for difference after treatment within the active rTMS group (p=.07), but not within the sham rTMS group (p=.88). RTMS resulted in no evidence of damage to WM on the side of stimulation. DTI may offer a unique modality to increase our understanding of mechanisms of action for rTMS.