Structure and function of renal glycosphingolipids.
Structure and function of renal glycosphingolipids.
复制标题
肾鞘糖脂的结构和功能。
DOI：
10.1152/ajprenal.1991.260.3.f291
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Radin,NS
中科院分区：
文献类型：
--
作者：
Shayman,JA;Radin,NS
詹姆斯·沙曼，和诺曼S。雷达rend鞘糖脂的结构和功能。Am. J. Physiol.260（肾脏液体电解质生理学29）：F291-F302，1991。鞘糖脂（GSL）是普遍存在的细胞组分，由三个不同的部分组成，长链碱，脂肪酸和碳水化合物。这些组分的结构存在显著的异质性，特别是在哺乳动物的肾脏中。仅基于碳水化合物结构的表征，肾GSL的结构研究揭示了约30种不同糖脂种类的存在。对肾脏GSL的代谢和生理学的研究虽然不太精确，但支持GSL在各种生理和病理生理过程中的介导作用。最好的研究是GSL表达和法布里病，溶血性尿毒综合征和细菌嗜性尿路之间的关联。其他研究支持GSL代谢与肾细胞生长、分化、离子转运、基质相互作用和信号转导之间的关联。肾脏;神经酰胺;两侧;神经节苷脂;鞘氨醇;阶段特异性胚胎抗原;葡糖神经酰胺; Conduritol B环氧化物; 1-苯基-2-癸酰氨基-3-吗啉代-1-丙醇糖鞘脂（GSL）是多种高度复杂的细胞成分，可能主要位于质膜中。它们以高度特异性分布于哺乳动物物种、器官、细胞类型和亚细胞结构域之间。已经假定GSL介导多种细胞功能，包括细胞生长、细胞-细胞相互作用和离子转运。许多研究人员，特别是神经科学和肿瘤学的研究人员，已经进行了许多观察，试图了解GSL结构和细胞功能之间的联系。然而，肾生理学家在很大程度上忽略了这些化合物作为各种重要生理过程的潜在介质。
SHAYMAN, JAMES A., AND NORMAN S. RADIN. Structureandfunctionof rend glycosphingolipids. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29): F291-F302, 1991.-Glycosphingolipids(GSLs) are ubiquitous cell components comprised of three distinct moieties, a long-chain base, a fatty acid, and a carbohydrate. Significant heterogeneity exists in the structure of each of these components, particularly in mammalian kidney. Structural studies of renal GSLs, based on the characterization of the carbohydrate structures alone, have revealed the existence of~ 30 distinct glycolipid species. Studies of the metabolism and physiology of renal GSLs, although less precise, nevertheless support roles for GSLs in the mediation of a variety of physiological and pathophysiological processes. Best studied are the associations between GSL expression and Fabry’s disease, hemolytic uremic syndrome, and bacterial tropism to the urinary tract. Other studies support an association between GSL metabolism and renal cell growth, differentiation, ionic transport, matrix interaction, and signal transduction. kidney; ceramide; cerebrosides; gangliosides; sphingosine; stage-specific embryonic antigens; glucosylceramide; conduritol B epoxide; l-phenyl-2 decanoylamino-3-morpholino-1-propanolGLYCOSPHINGOLIPIDS(GSLs) are diverse and highly complex cellular components localized primarily, perhaps, in the plasma membranes. They are distributed with high specificity between mammalian species, organs, cell types, and subcellular domains. GSLs have been postulated to mediate a wide variety of cellular functions, including cellular growth, cell-cell interactions, and ion transport. Many investigators, particularly in the neurosciences and oncology, have made many observations in attempting to understand the association between GSL structure and cellular function. Renal physiologists, however, have largely ignored these compounds as potential mediators of a variety of important physiological processes.