Targeting focal adhesions:Helicobacter pylori-host communication in cell migration.
Targeting focal adhesions:Helicobacter pylori-host communication in cell migration.
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DOI：
10.1186/1478-811x-6-2
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发表时间：
2008-08-06
期刊：
影响因子：
--
通讯作者：
Wessler S
中科院分区：
文献类型：
--
作者：
Schneider S;Weydig C;Wessler S
高度动态的基于整合素的粘着斑为将细胞肌动蛋白细胞骨架锚定到周围的细胞外基质提供了重要的结构基础。幽门螺杆菌（Helicobacter pylori，H. pylori）直接靶向整联蛋白，对上皮细胞形态和迁移产生严重影响，这可能导致体内胃上皮的破坏。本文综述了近年来关于H.幽门螺杆菌干扰宿主整联蛋白信号传导，从而解除对粘着斑和运动上皮细胞的肌动蛋白细胞骨架的调节。
Highly dynamic integrin-based focal adhesions provide an important structural basis for anchoring the cellular actin cytoskeleton to the surrounding extracellular matrix. The human pathogen Helicobacter pylori (H. pylori) directly targets integrins with drastic consequences on the epithelial cell morphology and migration, which might contribute to the disruption of the gastric epithelium in vivo. In this review, we summarize the recent findings concerning the complex mechanism through which H. pylori interferes with host integrin signaling thereby deregulating focal adhesions and the actin cytoskeleton of motile epithelial cells.