Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.
Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders.
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DOI：
10.9758/cpn.2016.14.3.231
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发表时间：
2016-08-31
期刊：
影响因子：
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通讯作者：
Ceylan ME
中科院分区：
文献类型：
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作者：
Evrensel A;Ceylan ME
粪便微生物移植已有1700年的历史。这种被遗忘的治疗方法在过去50年中再次投入使用。对微生物-肠-脑轴和粪便微生物移植的兴趣正在迅速增加。在神经精神疾病的发病机制方面获得了新的证据。在肠-脑轴领域有大量的实验和临床研究。关于粪便微生物群移植的信息有限。尽管如此，初步结果是有希望的。它通常用于治疗胃肠道疾病，如艰难梭菌感染，克罗恩病，溃疡性结肠炎。它也被实验性地用于治疗代谢和自身免疫性疾病。有病例报道，它对治疗自闭症、帕金森病、多发性硬化症、慢性疲劳综合征和肠易激综合征有效。它的实施很容易，是一种廉价可靠的治疗方法。但是，长期风险是未知的。此外，标准应用程序协议尚未建立。有很多问题需要解答。土耳其的一所大学今年获得了官方许可，开始应用粪便微生物移植。在这篇综述中，根据目前的信息，讨论了使用粪便微生物群移植的神经精神领域。
Fecal microbiota transplantation has a 1700-year history. This forgotten treatment method has been put into use again during the last 50 years. The interest in microbiota-gut-brain axis and fecal microbiota transplantation is rapidly increasing. New evidence is obtained in the etiopathogenesis of neuropsychiatric disorders. There is a large number of experimental and clinical researches in the field of gut-brain axis. There is limited information on fecal microbiota transplantation. Despite this, initial results are promising. It is commonly used in the treatment of gastrointestinal diseases such as Clostridium difficile infection, Crohn’s disease, ulcerative colitis. It is also experimentally used in the treatment of metabolic and autoimmune diseases. There are case reports that it is effective in the treatment of autism, Parkinson’s disease, multiple sclerosis, chronic fatigue syndrome and irritable bowel syndrome. Its implementation is easy, and it is a cheap and reliable treatment method. However, the long-term risks are unknown. Additionally, standard application protocols have not yet been established. There are a lot of questions to be answered. A university in Turkey has got official permission this year, and started to apply fecal microbiota transplantation. In this review, neuropsychiatric areas of use of fecal microbiota transplantation have been discussed in the light of the current information.