Age, sex, and ethnic variations in serum insulin concentrations among US youth
Age, sex, and ethnic variations in serum insulin concentrations among US youth
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DOI：
10.2337/dc06-1083
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发表时间：
2006-12-01
期刊：
影响因子：
16.2
通讯作者：
Cook, Stephen
中科院分区：
文献类型：
--
作者：
Ford, Earl S.;Li, Chaoyang;Cook, Stephen
目的 - 在美国，人们对青少年和年轻人血清胰岛素浓度的分布知之甚少。本研究的目的是描述美国青少年和年轻人人口特征中血清胰岛素的分布情况。 研究设计和方法 - 共有 1,791 名 12-19 岁的男性和女性受试者参与了 1999-2002 年国家健康和营养检查调查。结果——在男性参与者中，胰岛素的血清浓度从 12 岁到 14 岁有所增加，然后又下降。在女性参与者中，浓度在 13 岁时达到最高，然后在 19 岁时稳步下降。在 12-17 岁的参与者中，但在 18-19 岁的参与者中，在调整年龄和种族后，女性的平均对数转换浓度高于男性（P、Wald、F = 0.038 和 0. 125，分别）。在调整年龄和 BMI 百分位数后，12-17 岁非裔美国女性的平均对数转换浓度高于白人或墨西哥裔美国参与者。 18-19 岁的女性参与者或 12-19 岁的男性参与者中没有发现显着的种族差异。胰岛素浓度随着 BMI 水平的增加而大幅增加。结论 - 这些结果提供了美国青少年和年轻人代表性样本中胰岛素血清浓度的详细信息，可能有助于监测这一糖尿病和心血管疾病危险因素的未来趋势。
OBJECTIVE - Distributions of serum concentrations of insulin among adolescents and young adults are poorly understood in the U.S. The objective of this study was to describe the distribution of serum insulin across demographic characteristics of U.S. adolescents and young adults.RESEARCH DESIGN AND METHODS - A total of 1,791 male and female subjects aged 12-19 years who participated in the National Health and Nutrition Examination Surveys for 1999-2002 were included in the analyses.RESULTS - Among male participants, serum concentrations of insulin increased from age 12 to 14 years before decreasing. Among female participants, concentrations were highest at age 13 years before decreasing steadily through age 19 years. Among participants aged 12-17 years but not those aged 18-19 years, females had higher mean log-transformed concentrations than males (P, Wald, F = 0.038 and 0. 125, respectively) after adjusting for age and ethnicity. After adjusting for age and BMI percentile, mean log-transformed concentrations were higher in African-American females aged 12-17 years than in white or Mexican-American participants. No significant ethnic differences were found among female participants aged 18-19 years or male participants aged 12-19 years. Concentrations of insulin increased strongly with increasing levels of BMI.CONCLUSIONS - These results provide detailed information about serum concentrations of insulin in a representative sample of U.S. adolescents and young adults and may be useful to monitor future trends of this risk factor for diabetes and cardiovascular disease.