Mechanisms of current therapies for diabetes mellitus type 2.
Mechanisms of current therapies for diabetes mellitus type 2.
复制标题
目前 2 型糖尿病的治疗机制。
DOI：
10.1152/advan.00094.2012
复制
发表时间：
2012
影响因子：
2.1
通讯作者：
Thulé,PeterM
中科院分区：
文献类型：
--
作者：
Thulé,PeterM
在过去的十年中，可用于治疗高血糖症的药物种类迅速增加，最近的研究阐明了这些药物抗高血糖疗效的新机制。本文综述了目前在美国批准用于治疗糖尿病的药物的作用机制，胰岛素及其类似物除外。最后，它试图将这些机制整合到联合收割机产生糖尿病患者高血糖的病理生理因素的图式中。
The array of medications available for the treatment of hyperglycemia has increased rapidly in the previous decade, and recent investigations have clarified novel mechanisms underlying the antihyperglycemic efficacy of these drugs. This article reviews the mechanisms of action for medications currently approved to treat diabetes mellitus in the United States, with the exception of insulin and its analogs. Finally, it attempts to integrate these mechanisms into the schema of pathophysiological factors that combine to produce hyperglycemia in patients with diabetes mellitus.