THE MALIGNANCY OF DEMENTIA - PREDICTORS OF MORTALITY OF CLINICALLY DIAGNOSED DEMENTIA IN A POPULATION SURVEY OF SHANGHAI, CHINA
THE MALIGNANCY OF DEMENTIA - PREDICTORS OF MORTALITY OF CLINICALLY DIAGNOSED DEMENTIA IN A POPULATION SURVEY OF SHANGHAI, CHINA
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DOI：
10.1001/archneur.1994.00540240064017
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发表时间：
1994-12-01
影响因子：
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通讯作者：
ZHANG, MY
中科院分区：
文献类型：
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作者：
KATZMAN, R;HILL, LR;ZHANG, MY
目的：为了评估痴呆疾病对死亡风险的影响，同时考虑到其他条件，将缩短survival.Design：5年随访的社区调查dementia.Setting：5年的数据，获得了3531名受试者，年龄65岁及以上，谁参加了1987年人口调查dementia在上海，中国。根据人口统计学变量、基于临床评估结果的痴呆症诊断以及使用比例风险模型报告的15种流行医疗状况计算死亡的相对风险。在65至74岁的受试者中，死亡风险比为5.4（95%置信区间，2.0至14.6）阿尔茨海默病和7.2（95%置信区间，3.6至14.4）血管性痴呆。阿尔茨海默病的风险比与癌症的死亡风险比相似（5.6 [范围，2.9至10.9]）。在这个年龄组中，痴呆症并不常见，因此很少有人死于痴呆症。在75岁及以上的受试者中，阿尔茨海默病的死亡风险比为2.8（95%置信区间，2.1至3.6），血管性痴呆为3.5（95%置信区间，2.4至5.1），其他痴呆为3.6（95%置信区间，2.0至6.7）。因为这些痴呆症在75岁以上的受试者中很常见，23.7%的死亡风险可归因于这些疾病。结论：阿尔茨海默病和血管性痴呆都是真正的恶性疾病，是75岁以上人群死亡的主要危险因素。
Objective: To evaluate the effect of dementing illnesses on the risk of dying, taking into account other conditions that would shorten survival.Design: Five-year follow-up of community survey of dementia.Setting: Five-year data were obtained for the 3531 subjects, aged 65 years and older, who participated in the 1987 population survey of dementia in Shanghai, China.Main Outcome Measure: Time to death. Relative risks of dying were calculated for demographic variables, dementia diagnoses based on findings of clinical evaluations, and 15 reported prevalent medical conditions using the proportional hazards model.Results: In those subjects aged 65 to 74 years, the mortality risk ratio was 5.4 (95% confidence interval, 2.0 to 14.6) for Alzheimer's disease and 7.2 (95% confidence interval, 3.6 to 14.4) for vascular dementia. The risk ratio for Alzheimer's disease was similar to the mortality risk ratio for cancer (5.6 [range, 2.9 to 10.9]). In this age group, dementing illnesses were uncommon, and few deaths were therefore attributable to the dementing illnesses. In those subjects aged 75 years and older, the mortality risk ratios were 2.8 (95% confidence interval, 2.1 to 3.6) for Alzheimer's disease, 3.5 (95% confidence interval, 2.4 to 5.1) for vascular dementia, and 3.6 (95% confidence interval, 2.0 to 6.7) for ''other dementias.'' Because these dementing disorders were common in those subjects aged 75 years and older, 23.7% of the risk of death could be attributed to these disorders.Conclusions: Both Alzheimer's disease and vascular dementias are truly malignant and constitute major risk factors for death in persons older than 75 years.