Comparative skin penetration profiles of formulations including ultradeformable liposomes as potential nanocosmeceutical carriers
Comparative skin penetration profiles of formulations including ultradeformable liposomes as potential nanocosmeceutical carriers
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DOI：
10.1111/jocd.13410
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发表时间：
2020-04-12
影响因子：
2.3
通讯作者：
Montanari, Jorge
中科院分区：
文献类型：
--
作者：
Izquierdo, Maria Cecilia;Lillo, Cristian R.;Montanari, Jorge
超可变形脂质体是一种很有前途的药用活性物质载体，因为它们可以装载不同极性的分子，并且它们具有独特的渗透性能。目的虽然这些特征已经被测试过，但我们想知道它们在掺入不同的化妆品载体后是否可以保持其特殊的渗透性能，包括已经在市场上的商业产品。方法通过脂质膜重悬制备负载亲脂性和亲水性荧光探针的超可变形脂质体，然后挤出并掺入不同的载体和商业产品中。渗透测定在人类和猪的皮肤孵育，与Saarbrucken渗透模型，然后通过回收的探针或通过荧光microscopic.Results掺入ultradeformable脂质体的化妆品车辆没有改变他们的渗透在大多数情况下，为人类皮肤外植体。猪皮肤渗透呈现显着差异相比，人explores.Conclusions超可变形脂质体可作为通用的药妆载体在最终产品配方。
Background Ultradeformable liposomes are promising carriers for cosmeceutical actives as they can be loaded with molecules of different polarities, and they present unique penetration properties.Aims While those features have already been tested, we wanted to know whether their special penetration properties could be maintained after incorporation in diverse cosmetic vehicles, including commercial products already in the market.Methods Ultradeformable liposomes loaded with a lipophilic and a hydrophilic fluorescent probe were prepared by lipid film resuspension, followed by extrusion and incorporation to different vehicles and commercial products. Penetration was determined in human and pig skin by incubation, with the Saarbrucken penetration model, followed by the recovery of the probes or by fluorescence microscopy.Results The incorporation of ultradeformable liposomes to cosmetic vehicles did not alter their penetration in most of the cases for human skin explants. Pig skin penetration presented significant differences compared with human explants.Conclusions Ultradeformable liposomes could be useful as versatile cosmeceutical carriers in final product formulations.