BEAM-WALKING IN RATS - STUDIES TOWARDS DEVELOPING AN ANIMAL-MODEL OF FUNCTIONAL RECOVERY AFTER BRAIN INJURY
BEAM-WALKING IN RATS - STUDIES TOWARDS DEVELOPING AN ANIMAL-MODEL OF FUNCTIONAL RECOVERY AFTER BRAIN INJURY
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DOI：
10.1016/0165-0270(90)90154-8
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发表时间：
1990-02-01
影响因子：
3
通讯作者：
DAVIS, JN
中科院分区：
文献类型：
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作者：
GOLDSTEIN, LB;DAVIS, JN
虽然人们早就认识到人类在中风或头部受伤后恢复功能，但药物对恢复的直接影响直到最近才受到关注。在研究皮质损伤后药物操作对运动恢复的影响时，大鼠穿越狭窄高架梁的能力已被证明是特别有用的。然而，梁行走性能的恢复测试条件的影响还没有被调查。安非他明治疗促进恢复梁行走皮层病变后，无论是否“大规模”或“间隔”的试验。出乎意料的是，当用“大规模”试验进行测试时，假手术对照组的表现下降了。“刺激”假手术大鼠的臀部消除了这种性能下降，但导致了受损动物的恢复。结果表明，测试条件可以产生显着的影响梁行走性能，是重要的考虑时，解释药物对恢复过程的影响。
While it has long been recognized that humans recover function after stroke or head injury, the direct impact of drugs on recovery has only recently received attention. The ability of rats to traverse a narrow, elevated beam has proven to be particularly useful when studying the effects of pharmacologic manipulations on motor recovery following cortical injury. However, the effect of testing conditions on the recovery of beam-walking performance has not been investigated. Treatment with amphetamine facilitated recovery of beam-walking following cortical lesions regardless of whether ''massed'' or ''spaced'' trials were employed. Unexpectedly, the performance of sham-operated controls declined when tested with ''massed'' trials. ''Prodding'' sham-operated rats by tapping on the rump abolished this decline in perfomance, but resulted in enhanced recovery in lesioned animals. The results indicate that testing conditions can exert a significant influence on beam-walking performance and are important to consider when interpreting the impact of pharmacologic agents on the recovery process.