Long-term consequences of pain in human neonates
Long-term consequences of pain in human neonates
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DOI：
10.1016/j.siny.2006.02.007
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发表时间：
2006-08-01
影响因子：
3
通讯作者：
Peters, Jeroen W. B.
中科院分区：
文献类型：
--
作者：
Grunau, Ruth E.;Holsti, Liisa;Peters, Jeroen W. B.
早产儿在新生儿重症监护室（NICU）时的触觉阈值较低，而他们的生理系统不稳定且不成熟，可能使他们更容易受到反复侵入性手术的影响。关于NICU手术疼痛或早期手术后疼痛和触觉反应的文献较少，但不断增加。新生儿期反复疼痛对神经发育的长期影响有待进一步研究。然而，在NICU中存在多种压力来源，这有助于诱导高的总体“变静态负荷”，因此确定人类婴儿中新生儿疼痛的具体影响是具有挑战性的。(c)2006爱思唯尔有限公司保留所有权利。
The tow tactile threshold in preterm infants when they are in the neonatal intensive care unit (NICU), while their physiological systems are unstable and immature, potentially renders them more vulnerable to the effects of repeated invasive procedures. There is a small but growing literature on pain and tactile responsivity following procedural pain in the NICU, or early surgery. Long-term effects of repeated pain in the neonatal period on neurodevelopment await further research. However, there are multiple sources of stress in the NICU, which contribute to inducing high overall 'allostatic load', therefore determining specific effects of neonatal pain in human infants is challenging. (c) 2006 Elsevier Ltd. All rights reserved.