Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo
Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo
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DOI：
10.1364/oe.18.011372
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发表时间：
2010-05-24
期刊：
影响因子：
3.8
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
Razansky, R. Nika;Rosenthal, Amir;Ntziachristos, Vasilis
在破裂前检测高风险冠状动脉斑块仍然是一个未满足的临床挑战，部分原因是体内人类冠状动脉成像对分辨率和灵敏度的严格要求。为了满足这一需求，我们开发了一种近红外（NIR）荧光成像导管系统，用于对冠状动脉大小的血管中的动脉粥样硬化进行血管内分子成像，能够解析血管等中空器官中的二维荧光活动。基于旋转光纤设计，导管系统可垂直于旋转轴进行照明和检测，而自动回拉机制可实现沿血管的可视化，扫描速度高达 1.5 毫米/秒。我们展示了以前未记录的产生体内中空器官血管内近红外荧光图像的能力，并展示了使用血管模拟模型开发的系统的性能指标。这种成像方法适用于动脉粥样硬化生物标志物的体内分子成像，并且经过精心设计，可以无缝集成到心导管实验室中。 (C) 2010 美国光学学会
Detection of high-risk coronary arterial plaques prior to rupture remains an unmet clinical challenge, in part due to the stringent resolution and sensitivity requirements for in vivo human coronary arterial imaging. To address this need, we have developed a near-infrared (NIR) fluorescence imaging catheter system for intra-vascular molecular imaging of atherosclerosis in coronary artery-sized vessels, capable of resolving two-dimensional fluorescence activity in hollow organs, such as blood vessels. Based on a rotational fiber design, the catheter system illuminates and detects perpendicular to the rotational axis, while an automated pullback mechanism enables visualization along blood vessels with a scan speed of up to 1.5 mm/sec. We demonstrate the previously undocumented capacity to produce intravascular NIR fluorescence images of hollow organs in vivo and showcase the performance metrics of the system developed using blood vessel mimicking phantoms. This imaging approach is geared toward in vivo molecular imaging of atherosclerotic biomarkers and is engineered to allow seamless integration into the cardiac catheterization laboratory. (C) 2010 Optical Society of America