Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration.
Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration.
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骨髓脂肪组织：其起源、功能及其在骨重塑和再生中的调节
DOI：
10.1155/2018/7098456
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发表时间：
2018
影响因子：
4.3
通讯作者：
Kang N
中科院分区：
文献类型：
--
作者：
Li Q;Wu Y;Kang N
骨髓脂肪组织(MAT)是骨髓中唯一的脂肪储存库，与造血和骨稳态密切相关。MAT不同于外周脂肪组织，其来源的异质性、部位的特异性分布以及复杂和令人困惑的功能。虽然MAT被认为在造血、骨骼重塑和能量代谢中发挥作用，但其明确的特征仍需进一步研究。在这篇综述中，我们重点介绍了MAT的起源和分布、局部与骨稳态和造血龛的相互作用、代谢的系统内分泌调节以及基于MAT的促进骨形成的策略等方面的最新进展。
Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though MAT is indicated to function in hematopoiesis, skeletal remodeling, and energy metabolism, its explicit characterization still requires further research. In this review, we highlight recent advancement made in MAT regarding the origin and distribution of MAT, the local interaction with bone homeostasis and hematopoietic niche, the systemic endocrine regulation of metabolism, and MAT-based strategies to enhance bone formation.