A 250 μm × 57 μm Microscale Opto-electronically Transduced Electrodes (MOTEs) for Neural Recording.
A 250 μm × 57 μm Microscale Opto-electronically Transduced Electrodes (MOTEs) for Neural Recording.
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DOI：
10.1109/tbcas.2018.2876069
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发表时间：
2018-12
影响因子：
5.1
通讯作者：
Molnar AC
中科院分区：
文献类型：
--
作者：
Lee S;Cortese AJ;Gandhi AP;Agger ER;McEuen PL;Molnar AC
在活体动物体内记录神经活动，同时尽可能减少组织损伤，是了解神经系统的主要障碍之一。本文介绍了一种基于180 nm CMOS电路的无系绳光电神经接口技术，该技术与既可用作光伏又可用作发光二极管的AlGaAs二极管异质集成。这些微尺度光电转换电极（MOTE）由光学接口供电并通过光学接口进行通信，同时实现高时间分辨率的电气测量，而无需系绳或庞大的RF线圈。该MOTE芯片尺寸为250 μm × 57 μm，功耗为1 μ m，能够对神经信号进行捕获和编码，然后将编码后的信号发送出去。在15 KHz带宽下，实测本底噪声低至15 μVrms。
Recording neural activity in live animals in vivo with minimal tissue damage is one of the major barriers to understanding the nervous system. This paper presents the technology for a tetherless opto-electronic neural interface based on 180 nm CMOS circuits, heterogeneously integrated with an AlGaAs diode that functions as both a photovoltaic and light emitting diode. These microscale opto-electrically transduced electrodes (MOTEs) are powered by, and communicate through an optical interface, simultaneously enabling high temporal-resolution electrical measurements without a tether or a bulky RF coil. The MOTE presented here is 250 μm × 57 μm, consumes 1 of electrical power, and is capable of capturing and encoding neural signals before transmitting the encoded signals. The measured noise floor is as low as 15 μVrms at a 15 KHz bandwidth.