Distribution of MAP2 in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry
Distribution of MAP2 in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry
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DOI：
10.1177/002215540104900818
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发表时间：
2001-08-01
影响因子：
3.2
通讯作者：
Bertoni-Freddari, C
中科院分区：
文献类型：
--
作者：
Di Stefano, G;Casoli, T;Bertoni-Freddari, C
微管相关蛋白MAP2是一种细胞骨架蛋白，在神经元可塑性和维持分化神经元形态中起调节作用。采用定量免疫组织化学方法测定了MAP2在幼龄和老年大鼠海马和小脑中的分布。在老年和年轻大鼠中，密度分析显示海马CA1区MAP2免疫反应性显著降低（-93%），而小脑MAP2分布无差异。这些初步数据表明，在涉及记忆获取和巩固的大脑区域，map2依赖的神经可塑性和结构完整性随着年龄的增长而显著下降。
The microtubule-associated protein MAP2 is a cytoskeletal protein that plays a regulatory role in neuronal plasticity and in maintaining the morphology of differentiated neurons. MAP2 distribution was assessed in hippocampus and cerebellum of young and old rats by quantitative immunohistochemistry. In old vs young rats, densitometric analysis showed a significant decrease of MAP2 immunoreactivity in the hippocampus CA1 field (-93%), whereas no difference was found in cerebellar MAP2 distribution. These preliminary data suggest that in areas of the brain involved in memory acquisition and consolidation, MAP2-dependent neuroplasticity and structural integrity are significantly decreased in aging.