Oxidative Damage on RNA Nucleobases
Oxidative Damage on RNA Nucleobases
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DOI：
10.1007/978-3-642-54452-1_5
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发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Leumann, Christian J.
中科院分区：
文献类型：
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作者：
Kuepfer, Pascal A.;Leumann, Christian J.
氧化损伤的RNA最近受到越来越多的关注，并且与不同的神经退行性疾病密切相关。报道了氧化应激的原理及其对核酸的影响。与 DNA 相比，RNA 的氧化损伤迄今为止在文献中几乎没有描述。本文综述了这些在氧化应激下产生的已知稳定 RNA 碱基修饰的生物物理特性和潜在致突变性。此外，还讨论了细胞处理氧化 RNA 的可能机制。作为几种神经退行性疾病早期事件的转录后 RNA 修饰和 RNA 氧化不属于本综述的范围。
Oxidatively damaged RNA has recently gathered more attention and has been closely related to different neurodegenerative diseases. The principles of oxidative stress and its influence on nucleic acids are reported. In contrast to DNA oxidative lesions of RNA have been scarcely described in the literature so far. These known stable RNA base modifications which arise under oxidative stress are reviewed here with regard to their biophysical properties and their potential mutagenicity. Furthermore the possible mechanisms of how cells deal with oxidized RNA are discussed. Posttranscriptional RNA modifications and the oxidation of RNA as an early event in several neurodegenerative diseases are not in the scope of this review.