The effects of obesity on pulmonary function
The effects of obesity on pulmonary function
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DOI：
10.1136/adc.88.4.361
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发表时间：
2003-04-01
影响因子：
5.2
通讯作者：
Fok, TF
中科院分区：
文献类型：
--
作者：
Li, AM;Chan, D;Fok, TF
目的：（1）确定肥胖儿童人群中主要的肺功能异常;（2）评估肺功能损害的严重程度与双能X线吸收测定法（DEXA）评估的肥胖程度之间的相关性。64例肥胖患者接受了体格检查、标准化肺功能检查（肺活量测定法、肺容量和一氧化碳的单次呼吸扩散能力）和DEXA扫描测量。结果：16名女孩和48名男孩的中位年龄和体重指数（BMI）分别为12岁（IQR：10-14）和30.1kg/m2（IQR：27.2-32.8）。所有患者均无心肺疾病的临床证据。功能残气量降低（中位FRC 93%预测值，IQR：68.5-116.5%）和弥散能力受损（中位DLco 83.5%预测值，IQR：70.0-100.7%）是我们队列中最常见的异常，分别在30例（46%）和21例（33%）患者中观察到。3例患者出现阻塞性通气障碍。有显着的负相关的FRC，但不DLco与DEXA扫描测量值的减少程度之间的关系，但没有发现这样的关系时，BMI作为obesity.Conclusion指标：减少FRC和弥散功能障碍是最常见的异常发现在我们的队列肥胖患者。静态肺容量的减少与肥胖程度相关。
Aims: (1) To determine the predominant pulmonary function abnormality in our population of obese children; and (2) to assess the correlation between the severity of lung function impairment and the degree of obesity as assessed by dual energy x ray absorptiometry (DEXA).Methods: Sixty four obese patients underwent physical examination, standardised pulmonary function tests (spirometry, lung volumes, and single breath diffusion capacity for carbon monoxide), and DEXA scan measurements. The trunk and subtotal (total - head) body fat mass were used as surrogate index of body adiposity.Results: Sixteen girls and 48 boys with median age and body mass index (BMI) of 12 years (interquartile range (IQR): 10-14) and 30.1 kg/m(2) (IQR: 27.2-32.8) respectively were studied. None of the patients had clinical evidence of cardiopulmonary disease. Reduction in functional residual capacity (median FRC 93% predicted, IQR: 68.5-116.5%) and impairment of diffusion capacity (median DLco 83.5% predicted, IQR: 70.0-100.7%) were the most common abnormalities in our cohort, being observed in 30 (46%) and 21 (33%) patients respectively. Obstructive ventilatory impairment was found in three patients. There was significant negative correlation between the degree of reduction of FRC but not DLco with DEXA scan measurements, but such a relation was not found when BMI was used as the indicator of obesity.Conclusion: Reduction in FRC and diffusion impairment were the commonest abnormalities found in our cohort of obese patients. Reduction in static lung volume was correlated with the degree of obesity.