A prospective analysis of immunohistochemically determined estrogen receptor α and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog
A prospective analysis of immunohistochemically determined estrogen receptor α and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog
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DOI：
10.1354/vp.42-2-200
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发表时间：
2005-03-01
影响因子：
2.4
通讯作者：
Dios, R
中科院分区：
文献类型：
--
作者：
de las Mulas, JM;Millán, Y;Dios, R
对84例原发性犬乳腺癌患者进行为期18个月的观察，通过免疫组织化学检测雌激素受体(ER) α (ER α)和孕激素受体（PR）状态，以及公认的、公认的预后指标和宿主因素对无病期（无复发、无转移或合并）（DFP）的影响进行前瞻性分析。一种或两种受体的存在，以及肿瘤大小、淋巴结状态、组织学分级、血管内生长和坏死，对DFP具有预后价值。在多变量分析中，只有肿瘤大小和组织学分级被证明是独立的预后因素。所分析的宿主因素均不具有DFP的预后价值。228例肿瘤中有173例检测到erα、PR或两者兼有：70例检测到erα和PR；仅ERalpha；仅限公关。良性肿瘤和恶性肿瘤之间，以及良性肿瘤和恶性肿瘤的复杂、混合和简单组织学亚型之间，存在一种或两种受体的差异具有统计学意义。在恶性肿瘤组（n = 155）中，一种或两种受体的存在在小于3cm的肿瘤中更为常见，没有淋巴结转移，单纯性癌呈管状乳头状而不是实性生长，组织学分级为I级和II级，没有血管内生长和坏死，有淋巴细胞浸润。激素受体阳性肿瘤以良性肿瘤中erα阳性、pr阳性组和恶性肿瘤中erα阴性、pr阳性组最为常见。
The immunohistochemically determined estrogen receptor (ER) alpha (ERalpha) and progesterone receptor (PR) status, as well as recognized, well-accepted prognostic indicators and host factors were prospectively analyzed in 84 cases of primary canine mammary carcinoma for their effect on disease-free period (recurrence free, metastasis free, or combined) (DFP) after an observation period of 18 months. The presence of one or both receptors, as well as tumor size, lymph node status, histologic grading, intravascular growth, and necrosis, were of prognostic value for DFP. In multivariate analysis, only tumor size and histologic grading proved to be independent prognosticators. None of the host factors analyzed were of prognostic value for DFP. ERalpha, PR, or both were detected in 173 out of 228 tumors: 70 ERalpha and PR; 5 ERalpha only; 98 PR only. Statistically significant differences regarding the presence of one or both receptors were observed between benign and malignant tumors and between complex, mixed, and simple histologic subtypes of benign and malignant tumors. In the group of malignant tumors (n = 155), the presence of one or both receptors was more frequent in tumors smaller than 3 cm, without lymph node metastasis, with tubulopapillary rather than solid patterns of growth among simple carcinomas, of histologic grades I and II, without both intravascular growth and necrosis, and with lymphocyte cell infiltrates. The most frequent groups of hormone receptors-positive tumors were the ERalpha-positive and PR-positive group among benign and the ERalphaalpha-negative and PR-positive group among malignant tumors.