Orexin-A expression in human peripheral tissues
Orexin-A expression in human peripheral tissues
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DOI：
10.1016/s0303-7207(03)00206-5
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发表时间：
2003-07-31
影响因子：
4.1
通讯作者：
Sasano, H
中科院分区：
文献类型：
--
作者：
Nakabayashi, M;Suzuki, T;Sasano, H
食欲素A是一种存在于大脑中的神经肽，已知其调节进食和睡眠。在这项研究中，我们研究了食欲素-A在人体组织中的全身分布。在胸交感神经干的神经节细胞、胃肠道的肌间神经丛和内分泌细胞、胰腺的胰岛细胞和胎盘的合体滋养层细胞和蜕膜细胞中检测到食欲素-A的免疫反应性。在胃肠道，食欲素-A免疫反应性检测肌间神经丛从26孕周到出生。在胰腺的双重免疫染色中，绝大多数胰岛素阳性细胞同时对食欲素-A呈阳性。在肾脏、肾上腺、胰腺、胎盘、胃、回肠、结肠和结直肠上皮细胞中也检测到前食欲素原的mRNA表达。这些结果表明，食欲素-A的生产在各种人体外周组织和食欲素-A可能也发挥了重要作用，在一些外周器官。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Orexin-A is a neuropeptide present in the brain and is known to regulate feeding and sleeping. In this study, we examined the systemic distribution of orexin-A in human tissues. Immunoreactivity for orexin-A was detected in ganglion cells of the thoracic sympathetic trunk, myenteric plexuses and endocrine cells of the gastrointestinal tract, islet cells of the pancreas and syncytiotrophoblasts and decidual cells of the placenta. In the gastrointestinal tract, orexin-A immunoreactivity was detected in the myenteric plexuses from 26 gestational weeks to birth. In double immunostaining in the pancreas, a great majority of insulin-positive cells was simultaneously positive for orexin-A. mRNA expression for prepro-orexin was also detected in the kidney, adrenal gland, pancreas, placenta, stomach, ileum, colon and colorectal epithelial cells. These results suggest the production of orexin-A in various human peripheral tissues and orexin-A may also play important roles in some peripheral organs. (C) 2003 Elsevier Ireland Ltd. All rights reserved.