PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.

PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
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用氟-18标记的麦芽糖类对细菌感染的PET成像。

DOI:
10.1002/anie.201408533
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发表时间:
2014-12-15
影响因子:
16.6
通讯作者:
Murthy, Niren
Murthy, Niren
中科院分区:
化学1区
文献类型:
--
作者:
Ning, Xinghai;Seo, Wonewoo;Lee, Seungjun;Takemiya, Kiyoko;Rafi, Mohammad;Feng, Xuli;Weiss, Daiana;Wang, Xiaojian;Williams, Larry;Camp, Vernon M.;Eugene, Malveaux;Taylor, W. Robert;Goodman, Mark;Murthy, Niren

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一种新的正电子发射断层扫描(PET)示踪剂,由18 F标记的麦芽六糖(MH 18 F)组成,可以在体内对细菌进行成像,其灵敏度和特异性比氟脱氧葡萄糖(18 FDG)好几个数量级。MH18 F可以检测由少至105个大肠杆菌菌落形成单位(CFU)组成的早期感染,并且可以在体内鉴定细菌的耐药性。MH18F具有提高细菌感染诊断的潜力,因为它具有对细菌的高特异性和敏感性的独特组合。
A new positron emission tomography (PET) tracer, composed of 18F labeled maltohexaose (MH18F), can image bacteria in vivo with a sensitivity and specificity that is orders of magnitude better than fluorodeoxyglucose (18FDG). MH18F can detect early stage infections composed of as few as 105 E.coli colony forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH18F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
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