Galectin-3 and β-catenin are associated with a poor prognosis in serous epithelial ovarian cancer.
Galectin-3 and β-catenin are associated with a poor prognosis in serous epithelial ovarian cancer.
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Galectin-3 和 β-catenin 与浆液性上皮性卵巢癌的不良预后相关
DOI：
10.2147/cmar.s171146
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发表时间：
2018
影响因子：
3.3
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Liu Y;Xie L;Wang D;Li D;Xu G;Wang L;Zhou H;Yu Y;Lin Z;Lu H
本研究旨在探讨半乳糖凝集素-3（Galectin-3，Gal-3）和β-连环蛋白（β-catenin，β-catenin）在浆液性上皮性卵巢癌（serous epithelial ovarian cancer，SEOC）中的表达水平及其与SEOC临床病理特征的关系。采用免疫组化法检测74例SEOC患者标本中Gal-3和β-Catenin的表达，并采用SPSS19.0统计软件分析β-catenin和Gal-3蛋白表达与SEOC临床病理特征、治疗效果及预后的关系。Western blot检测Wnt/β-catenin通路蛋白在卵巢癌细胞株中的表达。SEOC中Gal-3和β-catenin的表达呈正相关（r=0.304和P=0.001）。Gal-3表达与SEOC的分级（P=0.037）、临床分期（P=0.034）、铂类耐药（P=0.030）和复发（P=0.001）有关。β-catenin与SEOC的复发有显著相关性（P=0.035）。铂类耐药（P=0.003）和Gal-3表达（P<0.001）是总生存期（OS）较差的独立危险因素。Gal-3强阳性组的OS显著低于阴性和弱阳性组（log-rank检验，P=0.001）。β-catenin阳性组的OS低于β-catenin阴性组（log-rank检验，P=0.034）。下调Gal-3表达可抑制卵巢癌细胞Wnt/β-catenin通路蛋白的表达。Gal-3可能激活SEOC中Wnt/β-catenin信号通路。因此，Gal-3可作为SEOC的预后因子。靶向Gal-3可能是治疗SEOC的一种有前途的新方法。
This study was designed to explore the expression levels of Galectin-3 (Gal-3) and β-catenin in serous epithelial ovarian cancer (SEOC), the linkage between their expressions, and the clinicopathological features of SEOC patients. Seventy-four SEOC patients’ specimens were detected for Gal-3 and β-Catenin expressions using immunohistochemistry, and the association between β-catenin or Gal-3 protein expressions and clinicopathological features, treatment effects, and prognosis were analyzed using SPSS 19.0. Western blot was used to analyze protein expressions of Wnt/β-catenin pathway in ovarian cancer cell lines. There was a statistically significant positive correlation between Gal-3 and β-catenin expressions in SEOC (r=0.304 and P=0.001). Gal-3 expression was related to the grade (P=0.037), clinical stage (P=0.034), platinum resistance (P=0.030), and recurrence (P=0.001) in SEOC. There was a significant correlation between β-catenin with recurrence in SEOC (P=0.035). Platinum resistance (P=0.003) and Gal-3 expression (P<0.001) were independent risk factors for poorer overall survival (OS). OS of the strongly positive Gal-3 group was significantly lower than that of the negative and weakly positive groups (log-rank test, P=0.001). OS of the positive β-catenin group was lower than that of the negative β-catenin group (log-rank test, P=0.034). Downregulating Gal-3 expression attenuated the protein expressions of Wnt/β-catenin pathway in ovarian cancer cell lines. Gal-3 might activate Wnt/β-catenin signaling pathway in SEOC. Hence, Gal-3 may serve as a prognostic factor for SEOC. Targeting Gal-3 may be a promising new treatment approach for SEOC.