Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
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DOI：
10.1111/j.1528-1167.2008.01765.x
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发表时间：
2009-02-01
期刊：
影响因子：
5.6
通讯作者：
Vining, Eileen P. G.
中科院分区：
文献类型：
--
作者：
Kossoff, Eric H.;Zupec-Kania, Beth A.;Vining, Eileen P. G.
生酮饮食（KD）是治疗儿童难治性癫痫的一种有效的非药物疗法。KD在世界各地的提供方式不同，偶尔在其管理方面存在显著差异。存在对用于临床和研究用途的更标准化的方案和管理建议的需要。2006年12月，查理基金会委托了一个由来自9个国家的26名儿科癫痫学家和营养师组成的小组，他们具有使用KD的特殊专业知识。该小组的创建是为了创建关于KD临床管理的共识声明。随后由儿童神经病学学会实践委员会认可，这份最终手稿解决了患者选择、KD前咨询和评估、特定饮食疗法选择、实施、补充、随访管理、不良事件监测和最终KD停药等问题。本文重点介绍了基于最佳证据的建议，包括协议和争议领域，未回答的问题和未来的研究。
The ketogenic diet (KD) is an established, effective nonpharmacologic treatment for intractable childhood epilepsy. The KD is provided differently throughout the world, with occasionally significant variations in its administration. There exists a need for more standardized protocols and management recommendations for clinical and research use. In December 2006, The Charlie Foundation commissioned a panel comprised of 26 pediatric epileptologists and dietitians from nine countries with particular expertise using the KD. This group was created in order to create a consensus statement regarding the clinical management of the KD. Subsequently endorsed by the Practice Committee of the Child Neurology Society, this resultant manuscript addresses issues such as patient selection, pre-KD counseling and evaluation, specific dietary therapy selection, implementation, supplementation, follow-up management, adverse event monitoring, and eventual KD discontinuation. This paper highlights recommendations based on best evidence, including areas of agreement and controversy, unanswered questions, and future research.