Type-specific and cross-reactive antibodies in gram-negative bacteremia.
Type-specific and cross-reactive antibodies in gram-negative bacteremia.
复制标题
革兰氏阴性菌血症中的类型特异性和交叉反应抗体。
DOI：
10.1056/nejm197208102870601
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
M. Johns
中科院分区：
文献类型：
--
作者：
W. R. Mccabe;B. Kreger;M. Johns
对175例革兰阴性菌血症患者进行了抗O-特异性和两种共有交叉反应抗原（普通肠细菌抗原[CA]和粗糙杆菌决定簇[Re]）的抗体滴度与休克或致死性结局的频率相关的研究。高滴度的O抗体不能阻止菌血症的发生，并且仅与休克和死亡频率的非常轻微的降低相关。CA抗体滴度的高度也与休克或致死性结局的频率无关。与此相反，休克和死亡是1/3的频繁与高滴度的患者（1：80或以上）的Re抗体。Re抗体的明显保护作用与O抗体的任何贡献无关。这些观察结果，再加上以前的动物研究，表明增强抵抗肠杆菌可能是通过免疫共享的交叉反应抗原。
Abstract Antibody titers to O-specific and two shared cross-reactive antigens (common entero-bacterial antigen [CA] and a determinant [Re] of rough bacilli) were related to the frequency of shock or a fatal outcome in 175 patients with gram-negative bacteremia. High titers of O antibody did not prevent development of bacteremia and were associated with only a very slight decrease in the frequency of shock and death. The height of antibody titers to CA also did not correlate with the frequency of shock or a fatal outcome. In contrast, both shock and death were 1/3 as frequent among patients with high titers (1:80 or above) of Re antibody. The apparent protective effect of Re antibody was independent of any contribution of O antibody. These observations, coupled with prior animal studies, suggest that enhancement of resistance to enterobacteria might be accomplished by immunization with shared cross-reactive antigens.