Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains.
Specific Regional and Age-Related Small Noncoding RNA Expression Patterns Within Superior Temporal Gyrus of Typical Human Brains Are Less Distinct in Autism Brains.
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DOI：
10.1177/0883073815602067
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发表时间：
2015-12
影响因子：
1.9
通讯作者：
Schumann CM
中科院分区：
文献类型：
--
作者：
Stamova B;Ander BP;Barger N;Sharp FR;Schumann CM
小的非编码RNA在整个大脑发育过程中调节信使RNA中起着关键作用，当改变时可能会产生深远的影响，导致自闭症谱系障碍（ASD）等疾病。我们评估了从幼儿期到成年期典型和ASD大脑中上级颞沟联合皮质和初级听觉皮质中的小型非编码RNA，包括微小RNA和小型核仁RNA。典型的小非编码RNA表达谱在ASD中不太明显，无论是在区域之间还是随着年龄的变化。典型的micro-RNA共表达协会在ASD大脑中不存在。miR-132、miR-103和miR-320 micro-RNA在ASD中失调，并且先前与自闭症谱系障碍相关。这些减少的区域和年龄相关的micro-RNA表达谱与先前报道的ASD大脑中减弱的信使RNA和长非编码RNA的发现一致。这项研究证明了ASD患者上级颞沟的改变，这是一个与社会障碍有关的区域，并且是第一个证明初级听觉皮层分子改变的研究。
Small noncoding RNAs play a critical role in regulating messenger RNA throughout brain development and when altered could have profound effects leading to disorders such as autism spectrum disorders (ASD). We assessed small noncoding RNAs, including microRNA and small nucleolar RNA, in superior temporal sulcus association cortex and primary auditory cortex in typical and ASD brains from early childhood to adulthood. Typical small noncoding RNA expression profiles were less distinct in ASD, both between regions and changes with age. Typical micro-RNA coexpression associations were absent in ASD brains. miR-132, miR-103, and miR-320 micro-RNAs were dysregulated in ASD and have previously been associated with autism spectrum disorders. These diminished region- and age-related micro-RNA expression profiles are in line with previously reported findings of attenuated messenger RNA and long noncoding RNA in ASD brain. This study demonstrates alterations in superior temporal sulcus in ASD, a region implicated in social impairment, and is the first to demonstrate molecular alterations in the primary auditory cortex.