Polymer-based hydrogel scaffolds for skin tissue engineering applications: a mini-review
Polymer-based hydrogel scaffolds for skin tissue engineering applications: a mini-review
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DOI：
10.1007/s10965-017-1278-4
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发表时间：
2017-06-28
影响因子：
2.8
通讯作者：
Lee, Young-Chul
中科院分区：
文献类型：
--
作者：
Jeong, Kwang-Hun;Park, Duckshin;Lee, Young-Chul
聚合物水凝胶由三维（3D）结构组成，具有通过氢键相互作用富含大量水的交联网络，使其高度亲水。由于其令人印象深刻的亲水特性和细胞无细胞毒性，聚合物水凝胶是用于组织细胞和组织以及器官再生的有用的组织工程工具。许多生物医学工程师和研究人员最近开始利用聚合物水凝胶作为组织或细胞培养环境，并作为组织工程和再生医学中器官稳定生长的支架。本文重点介绍聚合物水凝胶中的皮肤再生，其中皮肤是保护身体免受感染或物理或化学损伤的一种手段。一般来说，遭受轻微损伤或创伤的皮肤组织可以在相对短的时间内再生和愈合，而严重损伤可能需要移植或人造皮肤。出于这些目的，在体外环境中培养皮肤是必要的，并且使用聚合物水凝胶支架产生的环境需要与真实的环境相似并且对皮肤细胞生长安全。本文回顾了2000年后组织工程领域的皮肤再生研究，特别是聚合物水凝胶，并讨论了一些中心观点和关键问题。
Polymer hydrogels consist of a three-dimensional (3D) structure with cross-linked networks rich in a huge amount of water through hydrogen-bonding interactions, making them highly hydrophilic. Due to their impressive hydrophilic characteristics and cell non-cytotoxicity, polymer hydrogels are useful tissue engineering tools for the organization of cells and tissues and organ regeneration. Many biomedical engineers and researchers have recently begun to utilize polymer hydrogels as tissue or cell culture environments and as scaffolds for the stable growth of organs in tissue engineering and regeneration medicine. This paper focuses on skin regeneration in polymer hydrogels where skin is a means of protecting the body from infection or physical or chemical damage. Generally, skin tissue that has incurred minor damage or wounds can regenerate and heal in a relatively short time, while severe injuries may require transplantation or artificial skin. For those purposes, skin culturing in an in vitro environment is essential, and the environment produced using polymer hydrogel scaffolds needs to be both similar to the real environment and safe for skin cell growth. This paper reviews post-2000 skin regeneration research in the field of tissue engineering, focusing specifically on polymer hydrogels; it also discusses some of the central perspectives and key issues.