Probucol Suppresses Macrophage Infiltration and MMP Expression in Atherosclerotic Plaques of WHHL Rabbits
Probucol Suppresses Macrophage Infiltration and MMP Expression in Atherosclerotic Plaques of WHHL Rabbits
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DOI：
10.5551/jat.21600
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Fan, Jianglin
中科院分区：
文献类型：
--
作者：
Li, Shen;Liang, Jingyan;Fan, Jianglin
目的：普罗布考是一种降脂药物，常用于治疗家族性高胆固醇血症。然而，目前尚不清楚普罗布考是否可以改变动脉粥样硬化的病变质量。方法：我们研究了这种可能性，使用WHHL兔，人类家族性高胆固醇血症的模型。3月龄雄性WHHL家兔分别给予普罗布考（85 mg/kg/d）或阿托伐他汀（6 mg/kg/d）治疗16周，并与对照组比较其血脂水平和动脉粥样硬化病变。尽管如此，与对照组相比，普罗布考治疗导致主动脉正面病变显著减少39%（P0.05）。组织学检查显示，与对照组和阿托伐他汀组相比，普罗布考治疗组家兔的主动脉病变的特征是巨噬细胞减少，平滑肌细胞增加。此外，普罗布考治疗减少冠状动脉狭窄，增加斑块stability.Conclusions：这些结果表明，普罗布考治疗可能有有益的影响，对高胆固醇血症患者的斑块稳定性。
Aim: Probucol is a lipid-lowering drug that is often prescribed for the treatment of familial hypercholesterolemia. However, it is not known whether probucol can change the lesion quality of atherosclerosis.Methods: We examined this possibility using WHHL rabbits, a model of human familial hypercholesterolemia. Three-month-old male WHHL rabbits were treated with either probucol (85 mg/kg/day) or atorvastatin (6 mg/kg/day) for 16 weeks, and their plasma lipid levels and atherosclerotic lesions were compared with those of a control group.Results: We found that probucol treatment reduced the plasma cholesterol levels, but less remarkably than atorvastatin treatment. In spite of this, probucol treatment led to a prominent reduction of aortic en face lesions by 39% (P0.05), compared with those in the control. Histological examinations revealed that the aortic lesions of probucol-treated rabbits were characterized by reduced macrophages and increased smooth muscle cells compared with those from both the control and atorvastatin groups. Furthermore, probucol treatment reduced the coronary artery stenosis and increased the plaque stability.Conclusions: These results suggest that probucol treatment may have beneficial effects on the plaque stability of hypercholesterolemic patients.