Infusion of 2-Deoxy-D-Glucose into the Hepatic-Portal System Causes Eating: Evidence for Peripheral Glucoreceptors
Infusion of 2-Deoxy-D-Glucose into the Hepatic-Portal System Causes Eating: Evidence for Peripheral Glucoreceptors
复制标题
将 2-脱氧-D-葡萄糖输注到肝门系统会导致进食：外周葡萄糖感受器的证据
DOI：
10.1126/science.181.4102.858
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发表时间：
1973
期刊：
影响因子：
56.9
通讯作者：
M. Rezek
中科院分区：
文献类型：
--
作者：
D. Novin;D. A. Vanderweele;M. Rezek
注射2-脱氧葡萄糖到正常兔的肝门静脉系统增加进食到更大的程度和更短的潜伏期比注射2-脱氧葡萄糖到颈静脉或到hepaticportal循环的迷走神经切断兔。这些差异表明迷走神经介导的外周葡萄糖受体的存在，重要的食物摄入的启动。
Injections of 2-deoxyglucose into the hepatic-portal system of normal rabbits increased eating to a greater extent and with shorter latency than comparable injections of 2-deoxyglucose into the jugular vein or into the hepaticportal circulation of the vagotomized rabbit. These differences suggest the existence of vagally mediated peripheral glucoreceptors important in the initiation of food intake.