SIMILARITY OF COLORECTAL-CANCER IN CROHNS-DISEASE AND ULCERATIVE-COLITIS - IMPLICATIONS FOR CARCINOGENESIS AND PREVENTION
SIMILARITY OF COLORECTAL-CANCER IN CROHNS-DISEASE AND ULCERATIVE-COLITIS - IMPLICATIONS FOR CARCINOGENESIS AND PREVENTION
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DOI：
10.1136/gut.35.7.950
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发表时间：
1994-07-01
期刊：
影响因子：
24.5
通讯作者：
ZELIG, MP
中科院分区：
文献类型：
--
作者：
CHOI, PM;ZELIG, MP
结直肠癌是炎症性肠病患者最常见的恶性并发症。研究人员对 80 名患有克罗恩病 (CD) 或溃疡性结肠炎 (UC) 的结直肠癌患者进行了研究，诊断结直肠癌的中位年龄分别为 54.5 岁和 43.0 岁。诊断为癌症的中位病程较长（CD 15 年；UC 18 年）。大多数癌症是在患病八年以上后发生的（CD 75%；UC 90%）。诊断时患有多发性癌症的患者同样常见（CD 11%；UC 12%）。大多数患者癌症发生在肉眼可见的病变区域（CD 85%；UC 100%）。粘液性和印戒组织学特征同样常见（CD 29%；UC 21%）。两种疾病中不典型增生的发生率相似（CD 73%；UC 79%）。总体五年生存率也相似（CD 46%；UC 50%）。这些发现表明，并发 CD 和 UC 的癌症具有惊人相似的临床病理特征，并表明共同的潜在过程（例如慢性炎症）可能在结直肠癌的发病机制中很重要。
Colorectal cancer is the most frequent malignant complication in patients with inflammatory bowel disease. Eighty patients with colorectal cancer complicating Crohn's disease (CD) or ulcerative colitis (UC) with median ages at diagnosis of colorectal cancer of 54.5 years and 43.0 years respectively were studied. The median duration of disease to the diagnosis of cancer was long (CD 15 years; UC 18 years). Most cancers developed after more than eight years of disease (CD 75%; UC 90%). Patients with multiple carcinomas at diagnosis were equally common (CD 11%; UC 12%). Carcinoma occurred in the area of macroscopic disease in most patients (CD 85%; UC 100%). Mucinous and signet ring histological features were equally common (CD 29%; UC 21%). Dysplasia was present with similar frequency in both diseases (CD 73%; UC 79%). The overall five year survival rates were also similar (CD 46%; UC 50%). These findings show that carcinomas complicating CD and UC have strikingly similar clinicopathological features and suggest that a common underlying process, such as chronic inflammation, maybe important in the pathogenesis of colorectal carcinoma.